Cysteine protease inhibitors with 2-cyano-4-amino-pyrimidine...

Details Cysteine protease inhibitors with 2-cyano-4-amino-pyrimidine... Cysteine protease inhibitors with 2-cyano-4-amino-pyrimidine...

2006-09-26

2006-09-26

Rao, Deepak (Department: 1624)

Drug, bio-affecting and body treating compositions

Designated organic active ingredient containing

Heterocyclic carbon compounds containing a hetero ring...

C514S256000, C544S326000, C544S328000, C544S329000

Reexamination Certificate

active

07112589

ABSTRACT:
The invention provides compounds of formula I or a pharmaceutically acceptable salt or ester thereof (I), wherein the symbols have meaning as defined, which are inhibitors of cathepsin K and find use pharmaceutically for treatment of diseases and medical conditions in which cathepsin K is implicated, e.g. various disorders including inflammation, rheumatoid arthritis, osteoarthritis, osteoporosis and tumors

REFERENCES:
patent: 3202499 (1965-08-01), Knusli
patent: 4220770 (1980-09-01), Gass
patent: 2003/0032647 (2003-02-01), Yamada et al.
patent: 2328438 (1999-10-01), None
patent: 437911 (1960-11-01), None
patent: 198 17 459 (1999-10-01), None
patent: 1308811 (1973-03-01), None
patent: WO 97/09315 (1997-03-01), None
patent: WO 97/28128 (1997-08-01), None
patent: WO 01/19816 (2001-03-01), None
patent: WO 01/83460 (2001-11-01), None
patent: WO 01/96327 (2001-12-01), None
patent: WO 2004/000819 (2003-12-01), None
patent: WO 2004/000843 (2003-12-01), None
Wang et al., Cathepsin K inhibitor—polymer conjugates: potential drugs for the treatment of osteoporosis and rheumatoid arthritis, International Journal of Pharmaceutics, 277, pp. 73-79, 2004.
Simone, Oncology: Introduction, Cecil Textbook of Medicine, 20thedition, vol. 1, pp. 1004-1010, 1996.
Besson, Rees, Cottenceau and Pons, “Antimicrobial Evaluation of 3,1-Benzoxazin-4-ones, 3,1-Benzothiazin-4-ones, 4-Alkoxyquinazolin-2-carbonitriles and N-Arylimino-1,2,3,-dithiazoles”,Bioorg Med Chem Lett, vol. 6, No. 19, pp. 2343-2348 (1996).
Caravatti, Rahuel, Gay and Furet, “Structure-based Design of a Non-peptidic Antagonist of the SH2 Domain of GRB2”,Bioorg Med Chem Lett, vol. 9, No. 14, pp. 1973-1978 (1999).
Chang and Kim, “A Facile Synthesis of N-Arylcyanofomamidoximes, 4-Aryl-3-cyano-1,2,4-oxadiazin-5(6H)-ones, 2-Cyanoquinazoline-3-oxides, and 2-Cyanoquinazolines via 5-Arylmino-4-cholor-5H-1,2,3-dithiazoles”, Heterocycles, vol. 51, No. 11, pp. 2653-2666 (1999)—see CAPLUS Abstract No. 1999:710017.
Mori, Kawakami and Hashida, “Synthesis and Reactions of Cyan-1,3,5-triazines”,Nippon Kagaku Kaishi, vol. 4, pp. 396-400 (1990)—see CAPLUS Abstract No. 1990:515257.
Yamada, Matsuki, Kenji and Kikkawa, “Preparation of Heterocyclic Compounds as Phosphodiesterase V (PDE V) Inhibitors”, Japan (2001)—CAPLUS Abstract No. 2001:816647 [English equvalent of WO 01/83460].
On Line EPO Database Search for EP 0 850 228, Mar. 13, 1997 and WO 97/09/315, Mar. 13, 1997.

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