Cysteine protease derived from parasitic helminths

Details Cysteine protease derived from parasitic helminths Cysteine protease derived from parasitic helminths

1995-05-26

1998-07-07

Jagannathan, Vasu S.

Chemistry: molecular biology and microbiology

Enzyme , proenzyme; compositions thereof; process for...

Hydrolase

435212, C12N 950

Patent

active

057767580

ABSTRACT:
The immunosuppressive drug of the present invention can suppress both delayed-type hypersensitivity and antibody production against specific antigens and graft tissues and induce immunological tolerance to them by several administrations, instead of long continuous administration.
Cysteine protease, a secretory protein accumulated in the tissue of parasitic helminths, is extracted and purified. The cysteine protease is administered to a mammal and then tissue is implanted to the mammal. The immune response of the mammal against the tissue implant is suppressed even one year later.

REFERENCES:
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