Cysteine (NPYS)-containing peptides and use thereof for inhibiti

Details Cysteine (NPYS)-containing peptides and use thereof for inhibiti Cysteine (NPYS)-containing peptides and use thereof for inhibiti

1994-04-11

1995-06-27

Warden, Jill

Drug, bio-affecting and body treating compositions

Designated organic active ingredient containing

Peptide containing doai

530321, A61K 3800, C07K 700, C07K 706

Patent

active

054280206

ABSTRACT:
Peptides and pharmaceutically acceptable salts thereof of the following formula are provided ##STR1## wherein R is selected from the group consisting of Leu, Ile and Val,

REFERENCES:
patent: 4661471 (1987-04-01), Hawiger et al.
patent: 4683291 (1987-07-01), Zimmerman
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Puri et al., "Selective Inhibition of Thrombin- and Plasmin-Induced Platelet Aggregation by Phe-Gln-Val-Val-Cys (NpyS)-Gly-NH.sub.2 --An Examination of the Sequence Specificity", Blood 74(7), Suppl. 1, p. 287a (Nov. 1989).
Matsueda et al., Chem. Lett. 1857-1860 (1988).
Tenno et al., Int. J. Peptide Protein Res. 30, 93-98 (1987).
Matsueda et al., Chem. Lett. No. 2, 191-194 (Feb. 1990).
Matsueda et al., Abstract P1-A25 Kinins '87 Tokyo International Congress (1987).
Kimura et al., Analytical Biochemistry 122, 274-282 (1982).
Matsueda et al., "Cysteine Protease Inhibitors with S-(3-nitro-2-pyridinesulfenyl)-cysteine Residue in Affinity Analogs of Peptide Substrates", Kinins V Part B, Plenum Pub. Corp. (Sep. 1989), pp. 265-270.
Salvesin et al., Biochem. J. 234, 429-434 (1986).
Muller-Esterl, Atemw. Lungenkrkh., Jahrgang 14, 1 Supp.--Heft, S11-S22 (1988).
Kellerman et al., J. Biochem. 154, 471-478 (1986).

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