Cysteine-modified acidic fibroblast growth factor and methods of

Details Cysteine-modified acidic fibroblast growth factor and methods of Cysteine-modified acidic fibroblast growth factor and methods of

1994-01-31

1995-04-25

Baker, Keith

Drug, bio-affecting and body treating compositions

Designated organic active ingredient containing

Peptide containing doai

514 2, 514 8, 530399, A61K 3736

Patent

active

054098971

ABSTRACT:
Mutant human acidic fibroblast growth factor proteins are recombinantly produced having replaced cysteine residues with amino acids incapable of disulfide bond formation. The recombinantly produced mutant human acidic fibroblast growth factor proteins have improved biological activity in the absence of heparin when compared to wild-type recombinant human acidic fibroblast growth factor.

REFERENCES:
patent: 4444760 (1984-04-01), Thomas, Jr. et al.
patent: 4518584 (1985-05-01), Mark et al.
patent: 4677064 (1987-06-01), Mark et al.
patent: 4752585 (1988-06-01), Koths et al.
patent: 4835260 (1989-05-01), Shoemaker et al.
Ortega et eal. (1991) J. Biol. Chem. 266, 5842-5846.
Linemeyer et al. (1991) Growth Factors 3, 287.
Abraham et al., J. Cell Biochem. Supp. vol. 0. No. 11, Part A p. 50 (1987).
Anderson and Kingston, Proc. Natl. Acad. Sci. USA 80, pp. 6838-6842 (1983).
Armelin, Proc. Natl. Acad. Sci. USA 70, pp. 2702-2706 (1973).
Aviv and Leder, Proc. Natl. Acad. Sci USA 69, pp. 1408-1412 (1972).
Barritault et al., J. Neurosci. Res. 8, pp. 477-490 (1982).
Beaucage and Caruthers, Tetrahedron Letters 22, pp. 1859-1862 (1981).
Brosius, Gene 27, pp. 161-172 (1984).
DeBoer et al., Proc. Natl. Acad. Sci. USA 80, pp. 21-25 (1983).
Esch et al., Proc. Natl. Acad. Sci. USA 82, pp. 6507-6511 (1985).
Fiddes et al., J. Cell Biochem. vol. 32, Suppl. 10C, L146, p. 149 (1986).
Fourtanier et al., J. Invest. Dermatal. 87, pp. 76-80 (1986).
Gautschi-Sova et al., Biochem. Biophys. Res. Comm. 140, pp. 874-880 (1986).
Gentz et al., Proc. Natl. Acad. Sci. USA 78, pp.4936-4940 (1981).
Gimenez-Gallego et al., Science 230, pp. 1385-1388 (1985).
Gimenez-Gallego et al., Biochem. Biophys. Res. Commun. 138, pp. 611-617 (1986).
ospodarowicz et al., J. Cell Biol. 97, pp. 1677-1685 (1983).
Greisler et al., Tras. Am. Soc. Artif. Intern. Organs, vol. XXXII, 346-349 (1986).
Harper et al., Biochem. 25, pp. 4097-4103 (1986).
Hoffman, Growth 4, pp. 361-376 (1940).
Itakura et al., Sci. 198, pp. 1056-1063 (1977).
Jay et al., Science 23, pp. 541-545.
Kuo et al., Fed. Proc. 44, p. 695 (1985).
Linemeyer et al., Bio. Tech. 5, pp. 960-965 (1987).
Maniatis et al., Cell 15, pp. 687-701.
Matteucci and Caruthers, J. Am. Chem. Soc. 103, pp. 3185-3191 (1981).
Maxam and Gilbert, Proc. Natl. Acad. Sci., USA 74, pp. 560-564 (1977).
Maxam and Gilbert, Methods In Enzymology 65, pp. 499-560 (1980).
Norris et al., Nucleic Acids Res. 11, pp. 5103-5112 (1983).
O'Farrell, J. Biol. Chem. 250, pp. 4007-4021 (1975).
Sanger et al., Proc. Natl. Acad. Sci. USA 74, pp. 5463-5467 (1977).
Smithies et al., Science 202, pp. 1284-1289 (1987).
Suggs et al., Proc. Natl. Acad. Sci. USA 78, pp. 6613-6617 (1981).
Thomas et al., Proc. Natl. Acad. Sci. USA 81, pp. 357-361 (1984).
Thomas et al., Proc. Natl. Acad. Sci. USA 82, pp. 6409-6413 (1985).
Thomas and Gimenez-Gallego, TIBS 11, pp. 81-84 (1986).
Thomas et al., J. Biol. Chem. 255, pp. 5517-5520 (1980).
Trowell et al., J. Exp. Biol. 16, pp. 60-70 (1939).
Tseng et al., Eur. J. Biochem. 122, pp. 355-360 (1982).
Wensink et al., Cell 3, pp. 315-325 (1974).
Vlodavsky et al., J. Cell Biol. 83, pp. 468-486 (1979).
Zoller and Smith, Methods in Enzymology 100, pp. 468-500 (1983).
Zoller and Smith, DNA 3, pp. 479-488 (1984).
Bohlen et al., Proc. Natl. Acad. Sci. USA 81, pp. 5364-5368 (1984).
Burgess et al., Proc. Natl. Acad. Sci. USA 83, pp. 7216-7220 (1986).
Canalis et al., J. Clin. Invest. 79, pp. 52-58 (1987).
Crabb et al., Biochem., 25, pp. 4988-4993 (1986).
Esch et al., Biochem. Biophys. Res. Comm. 133, pp. 554-562 (1985).
Gimenez-Gallego et al., Biochem. Biophys. Res. Comm. 135, pp. 541-548 (1986).
Gospodarowicz et al., Proc. Natl. Acad. Sci. USA 73, pp. 4120-4124 (1976).
Gospodarowicz et al., Natl. Cancer Inst. Monog. 48, pp. 109-130 (1978).
Lemmon and Bradshaw, J. Cell. Biochem. 21, pp. 195-208 (1983).
Lobb and Fett, Biochem. 23, pp. 6296-6299 (1984).
Maciag et al., Science 225, pp. 932-935 (1984).
Maniatis et al., Molecular Cloning, A Lab., Cold Spring Harbor, N.Y. pp. 217-246, 270-294, 353-361 (1982).
Schoner et al., Proc. Natl. Acad. Sci. USA 83, pp. 8506-8510 (1986).
Schreiber et al., J. Cell Biol. 101, pp. 1623-1626 (1985).
Thomas et al., J. Prot. Chem. 6, pp. 163-171 (1987).
Seno, et al., Biochem. Biophys. Res. Comm. 151, pp. 701-708 (1988).

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