Cysteine-modified acidic fibroblast growth factor

Details Cysteine-modified acidic fibroblast growth factor Cysteine-modified acidic fibroblast growth factor

1992-08-28

1993-06-29

Wax, Robert A.

Drug, bio-affecting and body treating compositions

Designated organic active ingredient containing

Peptide containing doai

514 2, 530399, 435 694, 4351723, A61K 3736, C07K 1300

Patent

active

052234835

ABSTRACT:
Mutant human acidic fibroblast growth factor proteins are recombinantly produced having replaced cysteine residues with amino acids incapable of disulfide bond formation. The recombinantly produced mutant human acidic fibroblast growth factor proteins have improved biological activity in the absence of heparin when compared to wild-type recombinant human acidic fibroblast growth factor.

REFERENCES:
patent: 4752585 (1988-06-01), Koths et al.
patent: 4835260 (1989-05-01), Shoemaker et al.

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