Chemistry: natural resins or derivatives; peptides or proteins; – Proteins – i.e. – more than 100 amino acid residues – Lymphokines – e.g. – interferons – interlukins – etc.
Patent
1992-07-02
1994-10-25
Draper, Garnette D.
Chemistry: natural resins or derivatives; peptides or proteins;
Proteins, i.e., more than 100 amino acid residues
Lymphokines, e.g., interferons, interlukins, etc.
930141, 424 852, 424 856, C07K 1300
Patent
active
053590341
ABSTRACT:
Muteins of IL-6 and truncated IL-6 are prepared by recombinant DNA techniques. In the muteins, the cysteine residues that occur at positions, or at positions corresponding to positions, 45 and 51 of mature, native IL-6 have been replaced by other amino acids. The cysteine residues that occur at positions, or at positions corresponding to positions, 74 and 84 are retained. The molecule has biological activity that is at least comparable to that of native IL-6.
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Fowlkes Dana M.
Skelly Susan M.
Snouwaert John N.
Tackney Charles T.
Draper Garnette D.
Feit Irving N.
Imclone Systems Inc.
The University of North Carolina at Chapel Hill
Weiss Laura S.
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