Chemistry: natural resins or derivatives; peptides or proteins; – Proteins – i.e. – more than 100 amino acid residues – Lymphokines – e.g. – interferons – interlukins – etc.
Patent
1989-04-21
1992-11-24
Draper, Garnette D.
Chemistry: natural resins or derivatives; peptides or proteins;
Proteins, i.e., more than 100 amino acid residues
Lymphokines, e.g., interferons, interlukins, etc.
530402, 530404, 530405, 530403, 930141, 435 695, 435 6952, 424 851, 424 852, 424 8591, 525 541, C07K 1300, C12N 1524
Patent
active
051663228
ABSTRACT:
Cysteine added variants ("CAVs") of interleukin-3 are provided having one or more cysteine residues substituted for selected naturally occurring amino acid residues, or inserted into the polypeptide sequence, and preferably being further modified by deletion of certain N-terminal amino acids. Such CAVs may be additionally modified by the coupling of sulfhydryl reactive compounds to the introduced cysteine residue(s) without loss of bioactivity to produce selected homogeneously modified IL-3 and improved pharmaceutical compositions containing the same.
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Shaw Gray
Veldman Geertruida
Wooters Joseph L.
Cserr Luann
Draper Garnette D.
Eisen Bruce
Genetics Institute
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