Cystatin C as an antagonist of TGF-β and methods...

Details Cystatin C as an antagonist of TGF-β and methods... Cystatin C as an antagonist of TGF-β and methods...

2007-10-16

2007-10-16

Spector, Lorraine (Department: 1647)

Drug, bio-affecting and body treating compositions

Designated organic active ingredient containing

Peptide containing doai

C530S300000, C530S324000

Reexamination Certificate

active

10967093

ABSTRACT:
Disclosed are Cystatin C (CysC) homologues, including CystC homologues that act as antagonists or inhibitors of transforming growth factor-β (TGF-β). Also disclosed are methods to identify CystC homologues that are antagonists or inhibitors of TGF-β and compositions and therapeutic methods using CystC and homologues thereof to regulate the activity of TGF-β, and TGF-β-mediated tumor malignancy and invasion and other TGF-β-mediated fibrotic or proliferative conditions and diseases.

REFERENCES:
patent: 6534477 (2003-03-01), Nakai et al.
patent: 2002/0102711 (2002-08-01), Bandman et al.
patent: 2002/0137671 (2002-09-01), Nakai et al.
patent: 2005/0255114 (2005-11-01), Labat et al.
Vray et al. 2002. Cell Mol Life Sci. 59:1503-1512.
Reed CH. 2000. Br J Biomed Sci. 57:323-329.
Yan et al. 2003. Biol. Chem. 384:845-854.
Massague et al. 2000. Cell 103:295-309.
Wells 1990. Biochemistry 29:8509-8517.
Ngo et al. 1994. The Protein Folding Problem and Tertiary Structure Prediction. pp. 492-495.
Ogawa et al. 2003. J Med Food 6:317-322.
Corticchiato et al. 1992. Int J of Cancer 52:645-652.
Somanna et al. 2002. J Biol Chem. 277:25305-25312.
Coulibaly et al. 1999. Int. J Cancer 83:526-531.
Ogawa et al. 2002. BBA 1599:115-124.
Cornwall et al. 2003. Mol. and Cell. Endocr. 200:1-8.
Barrett et al., Biochem Biophys Res Commun. Apr. 30, 1984;120(2):631-6.
Brown et al., Protein Sci. Jan. 1997;6(1):5-12.
Grubb et al., Proc Natl Acad Sci U S A. May 1982;79(9):3024-7.
Konduri et al., Oncogene. Dec. 12, 2002;21(57):8705-12.
Kos et al., Int J Biol Markers. Jan.-Mar. 2000;15(1):84-9.
Solem et al., Biochem Biophys Res Commun. Oct. 30, 1990;172(2):945-51.
Somanna et al., J Biol Chem. Jul. 12, 2002;277(28):25305-12. Epub May 8, 2002.
Tang et al., J Clin Invest. Oct. 2003;112(7):1116-24.
Vray et al., Cell Mol Life Sci. Sep. 2002;59(9):1503-12. Review.

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