Organic compounds -- part of the class 532-570 series – Organic compounds – Carbohydrates or derivatives
Patent
1997-07-23
2000-05-02
Scheiner, Laurie
Organic compounds -- part of the class 532-570 series
Organic compounds
Carbohydrates or derivatives
435 691, 4352523, 536 231, 536 237, 536 221, C07H 2104
Patent
active
060574321
ABSTRACT:
The invention provides cysS polypeptides and DNA (RNA) encoding cysS polypeptides and methods for producing such polypeptides by recombinant techniques. Also provided are methods for utilizing cysS polypeptides to screen for antibacterial compounds.
REFERENCES:
Eriani, G., Dirheimer, G., and Gangloff, J. "Cysteinyl-tRNA synthetase: determination of the last E.coli aminoacyl-tRNA synthetase primary structure" Nucleic Acids Research, vol. 19, No. 2 pp. 265-269.
Hou, Y., Shiba, K., Mottes, C., and Schimmel, P. "Sequence determination and modeling of structural motifs for the smallest monomeric aminoacyl-tRNA synthetase" Proc Natl. Acad, Sci. USA, vol. 88, pp. 976-980, Feb. 1991.
Avalos, J., Corrochano, L., and Brenner, S. "Cysteinyl-tRNAS synthetase is a direct descendant of the first aminoacyl-tRNA synthetase" Federation of European Biochemical Soceities, vol. 286, No. 1,2 pp. 176-180, Jul. 1991.
Eriani, G., Dirheimer, G., and Gangloff, J. GenBank Submission Accession No. P21888.
Brown James R
Lawlor Elizabeth J
Reichard Raymond W
Deibert Thomas S.
Gimmi Edward R.
King William T.
Scheiner Laurie
SmithKline Beecham Corporation
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