CYP7 promoter-binding factors

Details CYP7 promoter-binding factors CYP7 promoter-binding factors

1999-03-31

2000-02-22

McKelvey, Terry

Chemistry: molecular biology and microbiology

Measuring or testing process involving enzymes or...

Involving nucleic acid

435 78, 435 29, 530300, 530324, 530325, 530326, 530327, 530328, 530350, C12Q 168, C12Q 102, C07K 700, C07K 1447, G01N 3353

Patent

active

06027901&

ABSTRACT:
The invention provides methods and compositions relating to CPF proteins which regulate transcriptional activation, and related nucleic acids. The polypeptides may be produced recombinantly from transformed host cells from the disclosed CPF encoding nucleic acids or purified from human cells. The invention provides isolated CPF hybridization probes and primers capable of specifically hybridizing with the disclosed CPF genes, CPF-specific binding agents such as specific antibodies, and methods of making and using the subject compositions in diagnosis, therapy and in the biopharmaceutical industry.

REFERENCES:
Ellinger-Ziegelbauer et al, Molecular and Cellular Biology, vol. 14: pp. 2786-2797, Apr. 1994.
Kudo et al. Molecular cloning of chicken FTZ-F1-related orphan receptors. Gene. Sep. 15, 1997, vol. 197, No. 1/2, pp. 261-268.
Peterson et al. Transcription factor based therapeutics: drugs of the future? Trends in Biotech. Jan. 1993, vol. 11, pp. 11-18.

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