CYP2D fluorescent assay reagents

Details CYP2D fluorescent assay reagents CYP2D fluorescent assay reagents

1999-07-12

2000-10-10

Woodward, Michael P.

Organic compounds -- part of the class 532-570 series

Organic compounds

Heterocyclic carbon compounds containing a hetero ring...

549400, C07D31112, C07D31118

Patent

active

061303429

ABSTRACT:
Novel fluorescent substrates of the human P450 enzyme CYP2D6 are provided. Also provided are methods for their manufacture and use. These substrates are useful in assessing CYP2D6 enzyme activity and in selecting compounds which inhibit CYP2D6 enzyme activity and, in particular, for identifying potential adverse drug interactions which are mediated by inhibition of CYP2D6 enzyme activity.

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Sailaja et al. Synthesis of 7-ethoxy-3-substituted-aminomethyl-4-methylcoumarins. Indian J. Chem., Sect. B, vol. 24B (2), pp. 206-207. (1985). No month found.

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