CYP19A1 polymorphisms

Details CYP19A1 polymorphisms CYP19A1 polymorphisms

2005-08-16

2009-02-03

Bausch, Sarae (Department: 1634)

Organic compounds -- part of the class 532-570 series

Organic compounds

Carbohydrates or derivatives

C435S006120, C435S091100

Reexamination Certificate

active

07485711

ABSTRACT:
Isolated CYP19A1 nucleic acid molecules that include a nucleotide sequence variant and nucleotides flanking the sequence variant are described, as well as CYP19A1 allozymes. Methods for determining the aromatase status of an individual also are provided, as are methods for determining if a subject is predisposed to certain clinical conditions.

REFERENCES:
patent: 5451683 (1995-09-01), Barrett et al.
patent: 5733729 (1998-03-01), Lipshutz et al.
patent: 5770722 (1998-06-01), Lockhart et al.
patent: 2001/0053519 (2001-12-01), Fodor et al.
patent: 2005/0228172 (2005-10-01), Wang
patent: WO 98/20019 (1998-05-01), None
GenBank Accession No. NM—000103.2 dated Jul. 23, 2006, 23 pages.
GenBank Accession No. NM—001785 dated May 7, 2006, 5 pages.
GenBank Accession No. NT—010194.16 dated Mar. 2, 2006, 5 pages.
GenBank Accession No. S52794 dated May 8, 1993, 1 page.
Ausubel et al. (eds.),Short Protocols in Molecular Biology, 1992, Second Edition, Chapters 8 and 11, Green Publishing Associates and John Wiley & Sons.
Brueggemeier et al., “Molecular pharmacology of aromatase and its regulation by endogenous and exogenous agents,”J. Steroid Biochem. Mol. Biol., 2001, 79:75-84.
Bulun et al., “The humanCYP19(aromatase P450) gene: update on physiologic roles and genomic organization of promoters,”J. Steroid Biochem. Mol. Biol., 2003, 86:219-224.
Caine et al., “Recombinant Human PhenylethanolamineN-Methyltransferase: Overproduction inEscherichia coli, Purification, and Characterization,”Protein Expr. Purif., 1996, 8:160-166.
Carlson et al., “Selecting a Maximally Informative Set of Single-Nucleotide Polymorphisms for Association Analyses Using Linkage Disequilibrium,”Am. J. Hum. Genet., 2004, 74:106-120.
Chadwick et al., “Heterozygote and Mutation Detection by Direct Automated Fluorescent DNA Sequencing Using a MutantTaqDNA Polymerase,”BioTechniques, 1996, 20(4):676-683.
Chin, “On the Preparation and Utilization of Isolated and Purified Oligonucleotides,” (CD-ROM and paper copy of first 2 pages and letter from Chin), Mar. 9, 2002.
Cibelli et al., “Cloned Transgenic Calves Produced from Nonquiescent Fetal Fibroblasts,”Science, 1998, 280:1256-1258.
Cleland, “Computer Programmes for Processing Enzyme Kinetic Data,”Nature, 1963, 198:463-465.
Cole et al., “The EBV-Hybridoma Technique and Its Application To Human Lung Cancer,”Monoclonal Antibodies and Cancer Therapy, 1985, Alan R. Liss, Inc., pp. 77-96.
Cote et al., “Generation of human monoclonal antibodies reactive with cellular antigens,”Proc. Natl. Acad. Sci. USA, 1983, 80:2026-2030.
Excoffier and Slatkin, “Maximum-Likelihood Estimation of Molecular Haplotype Frequencies in a Diploid Population,”Mol. Biol. Evol., 1995, 12(5):921-927.
Fullerton et al., “Apolipoprotein E Variation at the Sequence Haplotype Level: Implications for the Origin and Maintenance of a Major Human Polymorphism,”Am. J. Hum. Genet., 2000, 67:881-900.
Gordon et al., “Consed: A Graphical Tool for Sequence Finishing,”Genome Res., 1998, 8:195-202.
Guatelli et al., “Isothermal, in vitro amplification of nucleic acids by a multienzyme reaction modeled after retroviral replication,”Proc. Natl. Acad. Sci. USA, 1990, 87:1874-1878.
Hacia et al., “Detection of heterozygous mutations inBRCA1using high density oligonucleotide arrays and two-colour fluorescence analysis,”Nat. Genet., 1996, 14:441-447.
Hahn and Fishman, “Immunological Probe of Estrogen Biosynthesis. Evidence for the 2β-Hydroxylative Pathway in Aromatization of Androgens,”J. Biol. Chem., 1984, 259(3):1689-1694.
Hartl and Clark, “Chromosomes and Heredity,”Principles of Population Genetics, 3rd Edition, 1997, Sinauer Associates, Inc., (Sunderland, MA), pp. 96-106.
Haugen et al., “Amino-Terminal Sequence of Phenobarbital-Inducible Cytochrome P-450 from Rabbit Liver Microsomes: Similarity to Hydrophobic Amino-Terminal Segments of Preproteins,”Biochem. Biophys. Res. Comm., 1977, 77(3):967-973.
Hedrick, “An Introduction to Gametic Disequilibrium,”Genetics of Populations, 2nd edition, 2000, Jones and Bartlett (Sudbury, MA), pp. 396-405.
Huse et al., “Generation of a Large Combinatorial Library of the Immunoglobulin Repertoire in Phage Lambda,”Science, 1989, 246:1275-1281.
Hyrup and Nielsen, “Peptide Nucleic Acids (PNA): Synthesis, Properties and Potential Applications,”Bioorgan. Med. Chem., 1996, 4(1):5-23.
Köhler and Milstein, “Continuous cultures of fused cells secreting antibody of predefined specificity,”Nature, 1975, 256:495-497.
Kozbor and Roder, “The production of monoclonal antibodies from human lymphocytes,”Immunology Today, 1983, 4(3):72-79.
Lewis, “PCR's Competitors Are Alive and Well and Moving Rapidly Towards Commercialization,”Genetic Engineering News, 1992, 12(9):1-3.
Long et al., “An E-M Algorithm and Testing Strategy for Multiple-Locus Haplotypes,”Am. J. Hum. Genet., 1995, 56:799-810.
Myakishev et al., “High-Throughput SNP Genotyping by Allele-Specific PCR with Universal Energy-Transfer-Labeled Primers,”Genome Res., 2001, 11(1):163-169.
Nelson et al., “P450 superfamily: update on new sequences, gene mapping, accession numbers and nomenclature,”Pharmacogenetics, 1996, 6:1-42.
Nickerson et al., “PolyPhred: automating the detection and genotyping of single nucleotide substitutions using fluorescence-based resequencing,”Nucl. Acids Res., 1997, 25(14):2745-2751.
Prince et al., “Robust and Accurate Single Nucleotide Polymorphism Genotyping by Dynamic Allele-Specific Hybridization (DASH): Design Criteria and Assay Validation,”Genome Res., 2001, 11(1):152-162.
Sambrook et al.,Molecular Cloning, A Laboratory Manual, 1989, second edition, Sections 9.37-9.52,Cold Spring Harbor Press, Plainview, NY.
Schafer and Hawkins, “DNA variation and the future of human genetics,”Nat. Biotechnol., 1998, 16:33-39.
Schaid et al., “Score Tests for Association between Traits and Haplotypes when Linkage Phase Is Ambiguous,”Am. J. Hum. Genet., 2002, 70:425-434.
Sebastian and Bulun, “Genetics of Endocrine Disease. A Highly Complex Organization of the Regulatory Region of the Human CYP19 (Aromatase) Gene Revealed by the Human Genome Project,”J. Clin. Endocrin. Metab., 2001, 86(10):4600-4602.
Shastry, “Gene disruption in mice: Models of development and disease,”Mol. Cell. Biochem., 1998, 181:163-179.
Simpson et al., “Aromatase—A Brief Overview,”Annu. Rev. Physiol., 2002, 64:93-127.
Simpson et al., “Aromatase Cytochrome P450, The Enzyme Responsible for Estrogen Biosynthesis,”Endocr. Rev., 1994, 15(3):342-355.
Stoneking et al., “Population Variation of Human mtDNA Control Region Sequences Detected by Enzymatic Amplification and Sequence-specific Oligonucleotide Probes,”Am. J. Hum. Genet., 1991, 48:370-382.
Summerton and Weller, “Morpholino Antisense Oligomers: Design, Preparation, and Properties,”Antisense Nucleic Acid Drug Dev., 1997, 7:187-195.
Tajima, “Statistical Method for Testing the Neutral Mutation Hypothesis by DNA Polymorphism,”Genetics, 1989, 123:585-595.
Terwilliger and Ott, “Linkage Disequilibrium between Alleles at Marker Loci,”Handbook of Human Genetic Linkage, 1994, The Johns Hopkins University Press, Baltimore, pp. 188-193.
Underhill et al., “Detection of Numerous Y Chromosome Biallelic Polymorphisms by Denaturing High-Performance Liquid Chromatography,”Genome Res., 1997, 7:996-1005.
Wakayama et al., “Full-term development of mice from enucleated oocytes injected with cumulus cell nuclei,”Nature, 1998, 394(6691):369-374.
Weinshilboum and Wang, “Pharmacogenetics: Inherited variation in amino acid sequence and altered pro

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