Cynomolgus toll-like receptor 3

Chemistry: natural resins or derivatives; peptides or proteins; – Proteins – i.e. – more than 100 amino acid residues – Lymphokines – e.g. – interferons – interlukins – etc.

Reexamination Certificate

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Details

C424S085200, C435S069520, C435S320100, C435S471000, C435S325000, C536S023500

Reexamination Certificate

active

07982007

ABSTRACT:
Isolated polynucleotides encoding Cynomolgus monkey Toll-Like Receptor 3 (cynoTLR3), polypeptides obtainable from expression of these polynucleotides, recombinant cells, methods and uses of these are disclosed.

REFERENCES:
patent: 2003/0166001 (2003-09-01), Lipford
patent: 2006/0115475 (2006-06-01), Carton et al.
Bell et al, PNAS, 2005, vol. 102, No. 31, pp. 10976-10980.
Cho et al, Science, 2005, vol. 309, pp. 581-585.
Alexopoulou, et al., “Recognition of double-stranded RNA and activation of NF-κB by Toll-like receptor 3,” Nature, 413: 732-738 (2001).
Van Amersfoort, et al., Receptors, Mediators, and Mechanisms Involved in Bacterial Sepsis and Septic Shock, Clinical Microbiology Reviews, 16(3): 379-414 (2003).
Takeda, et al., “Microbial recognition by Toll-like receptors,” Journal of Dermatological Science, 34: 73-82 (2004).
Pierre Miossec, “An update on the cytokine network in rheumatoid arthritis,” Current Opinions in Rheumatology, 16: 218-222 (2004).
Ogata, et al., “Cytokine and Anti-cytokine Therapies for Inflammatory Bowel Disease,” Current Pharmaceutical Design, 9: 1107-1113 (2003).
Sanghavi, et al., “Increased Expression of TLR3 in Lymph Nodes during Simian Immunodeficiency Virus Infection: Implications for Inflammation and Immunodeficiency,” The Journal of Immunology, 175: 5314-5323 (2005).
PCT International Search Report dated May 7, 2009.

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