Cyclosporin soft capsule composition

Details Cyclosporin soft capsule composition Cyclosporin soft capsule composition

1995-04-24

1997-06-17

Page, Thurman K.

Drug, bio-affecting and body treating compositions

Preparations characterized by special physical form

Capsules

424451, 424455, 424456, 514784, 514785, 514786, 514937, 514962, 514970, 514975, 514885, 514 11, A61K 910, A61K 948, A61K 3813

Patent

active

056394748

ABSTRACT:
The present invention relates to a microemulsion concentrate containing cyclosporin as an active ingredient, dimethylisosorbide as a cosurfactant, oil and a surfactant which is suitable for the formulation of a soft capsule for oral administration, said cyclosporin, dimethyl isosorbide, oil and surfactant being present in the ratio of 1:1-5:1-5:2-10, and preferably in the ratio of 1:2-4:2-5:2-4:7, by weight. Since dimethylisosorbide has substantially no membrane permeation property, the soft capsule preparation according to the present invention is outstandingly stable in comparison with the soft capsules containing ethanol, propylene glycol, transcutol, glycofurol, etc., as a cosurfactant in the prior art, and further provides an advantage in that the pharmaceutical effect, appearance and composition content of the soft capsule according to the present invention are not changed.

REFERENCES:
patent: 5589455 (1996-12-01), Woo

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