Cyclosporin peptolides having an .alpha.-hydroxycarboxylic acid

Details Cyclosporin peptolides having an .alpha.-hydroxycarboxylic acid Cyclosporin peptolides having an .alpha.-hydroxycarboxylic acid

1988-06-20

1992-05-26

Chan, Christina

Drug, bio-affecting and body treating compositions

Designated organic active ingredient containing

Peptide containing doai

514885, 530317, 530323, 530335, 530338, 530345, 435 711, 435254, A61K 3702, C07K 750, C07K 754, C07K 1102

Patent

active

051168162

ABSTRACT:
Cyclic peptolides having the structure of a cyclosporin in which one amide linkage is replaced by an ester linkage are obtained by fermentation of fungal strains of the genus Cylindrotrichum Bonorden, or by cyclization of a hydroxy-undecapeptide. The cyclic peptolides have immunosuppressive, anti-inflammatory and anti-parasitic properties.

REFERENCES:
patent: 4220641 (1980-09-01), Traber et al.
patent: 4384996 (1983-05-01), Bollinger et al.
patent: 4649047 (1987-03-01), Kaswan
Rudinger, Peptide Hormones, Parsons (Ed.), U. Park Press, Baltimore, pp. 1-7 (1976).
Twentyman et al., Br. J. Cancer, vol. 56, pp. 55-57 (1987).

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