Cyclosporin derivatives, their preparation and the pharmaceutica

Details Cyclosporin derivatives, their preparation and the pharmaceutica Cyclosporin derivatives, their preparation and the pharmaceutica

1998-04-30

1999-11-02

Tsang, Cecilia J.

Drug, bio-affecting and body treating compositions

Designated organic active ingredient containing

Peptide containing doai

514 9, 530317, 530321, A61K 3702, C07K 512

Patent

active

059770678

ABSTRACT:
Cyclosporin derivatives of formula (I) in which R is H or a radical (Ia) or (Ib) as defined herein; R' is a radical (Ic) or (Id) as defined herein; and R"represents H or OH, with the proviso that R and R" are not simultaneously H, and pharmaceutically acceptable salts thereof, when they exist, are disclosed as useful for the treatment and/or prophylaxis of retrovirus infections. ##STR1##

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Bartz, et al, PNAS, USA, vol. 92, pp. 5381-5385, 1995.
Karpas et al, PNAS, USA, vol. 89, pp. 8351-8355, 1992.
Yarchoan, et al, J. Enzyme Inhibition, 1992, vol. 6, pp. 99-111.
Billich et al., "Mode of Action of SDZ NIM 811, a Nonimmunosuppressive Cyclosporin A Analog With Activity Against Human Immunodeficiency Virus (HIV) Type 1: Interference With HIV Protein Cyclophilin A Interactions," J. of Virology, 69(4):2451-2461 (1995).

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