Cyclosporin derivatives for the treatment of immune disorders

Details Cyclosporin derivatives for the treatment of immune disorders Cyclosporin derivatives for the treatment of immune disorders

2007-06-19

2008-12-23

Lukton, David (Department: 1654)

Chemistry: natural resins or derivatives; peptides or proteins;

Peptides of 3 to 100 amino acid residues

Cyclic peptides

C514S011400

Reexamination Certificate

active

07468419

ABSTRACT:
The present invention relates to a cyclosporin analog of the following formula (I) or a pro-drug or pharmaceutically acceptable salt thereof:whereinA is of the formula:where Q, W, X, Y, and Z are defined herein. In a second embodiment, the present invention relates to pharmaceutical compositions comprising pro-drugs or pharmaceutically acceptable salts of the compounds of the present invention and the use thereof for treating autoimmune diseases or for the prevention of organ transplantation rejection in a subject. In a third embodiment, the present invention relates to processes for the production of novel cyclosporin analogs of the present invention.

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Jose, Matthew (Nephrology 12(Suppl. 1), S66-S74, 2007).

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