Cyclosporin containing powder composition

Details Cyclosporin containing powder composition Cyclosporin containing powder composition

1994-11-23

1996-08-06

Russel, Jeffrey E.

Drug, bio-affecting and body treating compositions

Designated organic active ingredient containing

Peptide containing doai

424499, 514 9, 514770, 514970, A61K 914, A61K 3813, A61K 4704

Patent

active

055433936

ABSTRACT:
The present invention relates to a cyclosporin-containing powder composition which comprises cyclosporin, a non-ionic hydrophilic surfactant and a porous carrier. In addition, the present invention relates to a method for preparing the cyclosporin-containing powder composition which comprises dissolving cyclosporin and a non-ionic hydrophilic surfactant in an organic solvent, adding a porous carrier to the resulting solution and then evaporating the organic solvent from the mixture. The powder composition of the present invention is stable and does not require a special manufacturing technique when it is formulated. In addition, since the powder composition of the present invention does not contain an organic solvent, the necessity of a special package is excluded. Furthermore, the composition of the present invention provides an improved bioavailability which results in decrease of a single dosage, and therefore, can contribute to the alleviation of the side effects associated with cyclosporin.

REFERENCES:
patent: 4388307 (1983-06-01), Cavanak; Thomas
patent: 5047396 (1991-09-01), Orban et al.
patent: 5190753 (1993-03-01), Behrens et al.
patent: 5350741 (1994-09-01), Takada
patent: 5389382 (1995-02-01), List et al.
Chem. Pharm. Bull. vol. 37, No. 9, issued 1989, Takada et al, "Enteric Solid Dispersion of cyclosporin A . . . ", pp. 2542-2544.
Pharmaceutical Research, vol. 6, No. 11, pp. 958-960, 1989, Lorenz Hahn, et al., "Solid Surfactant Solutions of Active Ingredients in Sugar Esters".
International Journal of Pharmaceutics, vol. 92, pp. 197-202, 1993, P. C. Lerk, et al., "Application of Sucrose Laurate, A New Pharmaceutical Excipient, in Peroral Formulations of Cyclosporin A".

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