Cyclosporin-containing pharmaceutical compositions

Details Cyclosporin-containing pharmaceutical compositions Cyclosporin-containing pharmaceutical compositions

1998-03-12

1999-09-28

Tsang, Cecilia J.

Drug, bio-affecting and body treating compositions

Designated organic active ingredient containing

Peptide containing doai

424451, 530317, A61K 3800, A61K 948

Patent

active

059588764

ABSTRACT:
The present invention relates to a cyclosporin-containing soft capsule preparation which contains a composition containing cyclosporin as an active ingredient; a non-hydrophilic component propylene carbonate or a mixture of propylene carbonate and a hydrophilic component polyethylene glycol, one or a mixture of two or more selected from the group consisting of an esterified compound of fatty acid and primary alcohol, medium chain fatty acid triglyceride and fatty acid monoglyceride as an oil component; and a surfactant having an HLB (Hydrophilic Lipophilic Balance) value of 8 to 17.

REFERENCES:
patent: 4388307 (1983-06-01), Cavanak
patent: 5342625 (1994-08-01), Hauer et al.
patent: 5589455 (1996-12-01), Woo
patent: 5626872 (1997-05-01), Vasquez
Wade et al., Handbook of Pharmaceutical Excipients (1994), pp. 355-361, 648.
Ainley Wade and Paul J. Weller, (eds.), Handbook of Pharmaceutical Excipients, 2nd ed., "Propylene Carbonate," pp. 405-406.

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