Cyclosporin compounds, their preparation and the pharmaceutical

Drug – bio-affecting and body treating compositions – Designated organic active ingredient containing – Peptide containing doai

Patent

Rate now

  [ 0.00 ] – not rated yet Voters 0   Comments 0

Details

514 9, 530317, A61K 3702, C07K 512

Patent

active

059942991

ABSTRACT:
Cyclosporin compounds of formula (I): ##STR1## wherein Alk and R are as defined herein, or a pharmaceutically acceptable salt thereof, which derivatives are useful in the treatment and/or prophylaxis of retrovirus infections.

REFERENCES:
patent: 4703033 (1987-10-01), Seebach
patent: 4771122 (1988-09-01), Seebach
patent: 4814323 (1989-03-01), Andrieu et al.
Billich et al, J. of Virology, Apr. 1995, pp. 2451-2461.
Billich et al., "Mode of Action of SDZ NIM 811, a Nonimmunosuppressive Cyclosporin A Anaolog with Activity Against Human Immunodeficiency Virus (HIV) Type 1: Interference with HIV Protein Cyclophilin A Interactions," J. of Virology, 69(4):2451-2461, (1995).
Papageorgiou et al., "Anti HIV-1 Activity of a Hydrophilic Cyclosporin Derivative With Improved Binding Affinity to Cyclophilin A," Bioorganic & Medicinal Chemistry Letters, 6(1):23-26 (1996).
Mikol et al., "The Role of Water Molecules in the Structure-Based Design of (5-Hydroxynorvaline)-2-cyclosporin: Synthesis, Biological Activity, and Crystallographic Analysis With Cyclophilin A," J. Med. Chem., 38(17):3361-3367 (1995).

LandOfFree

Say what you really think

Search LandOfFree.com for the USA inventors and patents. Rate them and share your experience with other people.

Rating

Cyclosporin compounds, their preparation and the pharmaceutical does not yet have a rating. At this time, there are no reviews or comments for this patent.

If you have personal experience with Cyclosporin compounds, their preparation and the pharmaceutical , we encourage you to share that experience with our LandOfFree.com community. Your opinion is very important and Cyclosporin compounds, their preparation and the pharmaceutical will most certainly appreciate the feedback.

Rate now

     

Profile ID: LFUS-PAI-O-1672486

  Search
All data on this website is collected from public sources. Our data reflects the most accurate information available at the time of publication.