Cyclosporin compounds, their preparation and the pharmaceutical

Details Cyclosporin compounds, their preparation and the pharmaceutical Cyclosporin compounds, their preparation and the pharmaceutical

1997-12-23

1999-11-30

Tsang, Cecilia J.

Drug, bio-affecting and body treating compositions

Designated organic active ingredient containing

Peptide containing doai

514 9, 530317, A61K 3702, C07K 512

Patent

active

059942991

ABSTRACT:
Cyclosporin compounds of formula (I): ##STR1## wherein Alk and R are as defined herein, or a pharmaceutically acceptable salt thereof, which derivatives are useful in the treatment and/or prophylaxis of retrovirus infections.

REFERENCES:
patent: 4703033 (1987-10-01), Seebach
patent: 4771122 (1988-09-01), Seebach
patent: 4814323 (1989-03-01), Andrieu et al.
Billich et al, J. of Virology, Apr. 1995, pp. 2451-2461.
Billich et al., "Mode of Action of SDZ NIM 811, a Nonimmunosuppressive Cyclosporin A Anaolog with Activity Against Human Immunodeficiency Virus (HIV) Type 1: Interference with HIV Protein Cyclophilin A Interactions," J. of Virology, 69(4):2451-2461, (1995).
Papageorgiou et al., "Anti HIV-1 Activity of a Hydrophilic Cyclosporin Derivative With Improved Binding Affinity to Cyclophilin A," Bioorganic & Medicinal Chemistry Letters, 6(1):23-26 (1996).
Mikol et al., "The Role of Water Molecules in the Structure-Based Design of (5-Hydroxynorvaline)-2-cyclosporin: Synthesis, Biological Activity, and Crystallographic Analysis With Cyclophilin A," J. Med. Chem., 38(17):3361-3367 (1995).

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