Cyclopropylindole prodrugs

Details Cyclopropylindole prodrugs Cyclopropylindole prodrugs

1995-06-07

1997-07-08

McKane, Joseph

Organic compounds -- part of the class 532-570 series

Organic compounds

Heterocyclic carbon compounds containing a hetero ring...

548430, 548433, 5483117, 548181, 548455, 548490, 548491, C07D20956, C07D40514

Patent

active

056462980

ABSTRACT:
The present invention describes cyclopropylindole cytotoxic prodrugs of formulas (I), (II) and (III) as shown in the specification. The present invention is also directed to a method for the site-specific treatment of neoplastic diseases in a mammal which method includes the following steps: (i) administering to an afflicted mammal an effective amount of a targeting agent- enzyme donor peptide conjugate wherein the targeting agent is selected from the group of antibodies, monoclonal antibodies, adhesion molecules and tumor cell surface binding ligands; (ii) administering to the afflicted mammal an effective amount of an enzyme acceptor dimer thereby forming active enzymatic sites at a tumor cell surface; and (iii) administering to the afflicted mammal a therapeutically effective amount of an enzyme-activateable, cytotoxic pro-drug thereby releasing the cytotoxic drug at the tumor site.

REFERENCES:
patent: 4708929 (1987-11-01), Henderson
CA 124: 145899p Preparation of . . . prodrugs. Tietz, 1995.

Affiliated with

Also associated with

Rating

Cyclopropylindole prodrugs does not yet have a rating. At this time, there are no reviews or comments for this patent.

If you have personal experience with Cyclopropylindole prodrugs, we encourage you to share that experience with our LandOfFree.com community. Your opinion is very important and Cyclopropylindole prodrugs will most certainly appreciate the feedback.

Rate now

Comments { 0 }

Profile ID: LFUS-PAI-O-2409666