Cyclopropyl squalene derivatives and their use as inhibitors of

Details Cyclopropyl squalene derivatives and their use as inhibitors of Cyclopropyl squalene derivatives and their use as inhibitors of

1991-06-28

1992-04-07

Waddell, Frederick E.

Drug, bio-affecting and body treating compositions

Designated organic active ingredient containing

Ether doai

514824, A61K 31075

Patent

active

051029154

ABSTRACT:
The present invention relates to a group of compounds which are novel squalene derivatives containing the cyclopropyloxy functionality and which act to inhibit the synthesis of cholesterol in mammals and in fungi.

REFERENCES:
patent: 2330979 (1943-10-01), Krantz et al.
patent: 4891367 (1990-01-01), Angelastro et al.
Sen et al., J. Am. Chem. Soc. 111,1508-1510 (1989).
Taylor et al., J. Biol. Chem. 261(320, 15039-44 (1986).
Cattel et al., Lipids 21(1), 31-38 (1986).

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