Cyclopropyl pyrrolidine orexin receptor antagonists

Organic compounds -- part of the class 532-570 series – Organic compounds – Heterocyclic carbon compounds containing a hetero ring...

Reexamination Certificate

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C548S222000, C548S255000, C544S284000, C544S356000, C544S265000, C544S238000, C546S115000, C546S271700, C514S249000, C514S252060, C514S255050, C514S263200, C514S275000, C514S338000, C514S367000, C514S375000, C514S395000

Reexamination Certificate

active

08030495

ABSTRACT:
The present invention is directed to cyclopropyl proline bis-amide compounds which are antagonists of orexin receptors, and which are useful in the treatment or prevention of neurological and psychiatric disorders and diseases in which orexin receptors are involved. The invention is also directed to pharmaceutical compositions comprising these compounds and the use of these compounds and compositions in the prevention or treatment of such diseases in which orexin receptors are involved.

REFERENCES:
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patent: 6927200 (2005-08-01), Bodet et al.
patent: 7582659 (2009-09-01), Fukuda
patent: 2004/0122017 (2004-06-01), Chader et al.
patent: 2010/0016401 (2010-01-01), Aissaoui et al.
patent: 2010/0204285 (2010-08-01), Aissaoui et al.
patent: WO 2004080463 (2004-09-01), None
patent: WO 2008/038251 (2008-04-01), None
patent: WO 2008/081399 (2008-07-01), None
patent: WO 2009/004584 (2009-01-01), None
patent: WO 2009/016560 (2009-02-01), None
patent: WO 2009/016564 (2009-02-01), None
International Preliminary Report on Patentability for WO 2008/150364, (Nov. 24, 2009).
Coleman, et al., Expert Opin. Ther. Patents (2010), 20(3), 307-324.

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