Cyclopropyl derivatives, preparation method there-of and applica

Details Cyclopropyl derivatives, preparation method there-of and applica Cyclopropyl derivatives, preparation method there-of and applica

1997-08-15

1998-11-10

Chang, Ceila

Drug, bio-affecting and body treating compositions

Designated organic active ingredient containing

Having -c-, wherein x is chalcogen, bonded directly to...

546225, 546227, A61K 31445, C07D21134

Patent

active

058344900

ABSTRACT:
Cyclopropyl derivatives of formula (I) wherein R is cyclopropyl or methyllopropyl are prepared by reaction of 2,6-dibromohexanoyl chloride with 2,6-dimethylaniline in the presence of a base at 0.degree.-25.degree. C. to give 2,6-dibromohexanoyl-2,6-dimethylanilide which subsequently is reacted with R--NH.sub.2 (wherein R is cyclopropyl or methylcyclopropyl) at 70.degree.-100.degree. C. The compounds are useful as antiarrhythmic agents and as local anaesthetic agents.

REFERENCES:
1958 Chem. Abst. 52: #14609e.
1982 Chem. Abst. 97: 190 174482b.
Blaney et al. (1983) J. Medicin. Chem. 26:1747-52.
Ekenstam et al. (1958) Org. Chem. 10:14609.
Feldman et al. (1988) Anesth. Analg 67:1047-52.
Local Anesthetics (1987) G.R. Strickark ed., p. 191.
The Merck Index (1996) XII ed., p. 8418 (Record #8417).

Affiliated with

Also associated with

Rating

Cyclopropyl derivatives, preparation method there-of and applica does not yet have a rating. At this time, there are no reviews or comments for this patent.

If you have personal experience with Cyclopropyl derivatives, preparation method there-of and applica, we encourage you to share that experience with our LandOfFree.com community. Your opinion is very important and Cyclopropyl derivatives, preparation method there-of and applica will most certainly appreciate the feedback.

Rate now

Comments { 0 }

Profile ID: LFUS-PAI-O-1517132