Drug – bio-affecting and body treating compositions – Designated organic active ingredient containing – Having -c- – wherein x is chalcogen – bonded directly to...
Reexamination Certificate
2008-04-15
2008-04-15
Seaman, D. Margaret (Department: 1625)
Drug, bio-affecting and body treating compositions
Designated organic active ingredient containing
Having -c-, wherein x is chalcogen, bonded directly to...
C514S390000, C548S204000, C548S110000, C548S182000, C548S186000
Reexamination Certificate
active
07358266
ABSTRACT:
The invention relates to cis- and trans-12, 13-cyclopropyl and 12,13-cyclobutyl epothilones of formula I to IVwherein Ar is a radical represented by the following structure:and the other radicals and symbols have the meanings as defined herein; to their chemical synthesis and biological evaluation; their use in the treatment of neoplastic diseases and to pharmaceutical preparations containing such compounds. The compounds described herein are potent tubulin polymerization promoters and cytotoxic agents.
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Altmann Karl-Heinz
Namoto Kenji
Nicolaou Kyriacos C.
Ritzen Andreas
Shoji Mitsuru
Fitting Thomas
Lewis Donald G.
Seaman D. Margaret
The Scripps Research Institute
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