Cyclopropyl analogs as anti-estrogenic, anti-tumor and female fe

Details Cyclopropyl analogs as anti-estrogenic, anti-tumor and female fe Cyclopropyl analogs as anti-estrogenic, anti-tumor and female fe

1987-09-21

1989-11-07

Dixon, Jr., William R.

Drug, bio-affecting and body treating compositions

Designated organic active ingredient containing

Halogenated hydrocarbon doai

424422, 424430, 424433, A61K 3103

Patent

active

048793159

ABSTRACT:
Anti-estrogenic cyclopropyl analogs such as 1,1-dichlorocis-2,3-diphenylcyclopropane, when administered to a subject function as anti-tumor agents to prevent the development of estrogen-dependent tumors in the subject and substantially arrest the growth and metastatic involvement of existing estrogen-dependent tumors in the subject. Further, the anti-estrogenic cyclopropyl analogs may be used as anti-estrogenic agents and as fertility agents in the treatment of female infertility. The cyclopropyl analogs useful as anti-tumor, anti-estrogenic and female fertility agents have the general structure ##STR1## wherein: X is a halogen or hydrogen atom;

REFERENCES:
Margarian and Benjamin, "Synthesis of Cyclopropyl Analogs of Stilbene and Stilbenediol as Possible Antiestrogens", J. Pham. Sci., 64, 1626-32 (1975).

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