Cyclopropyl amines as modulators of the histamine H 3 receptor

Drug – bio-affecting and body treating compositions – Designated organic active ingredient containing – Heterocyclic carbon compounds containing a hetero ring...

Reexamination Certificate

Rate now

  [ 0.00 ] – not rated yet Voters 0   Comments 0

Details

C544S060000

Reexamination Certificate

active

07910582

ABSTRACT:
Certain cyclopropyl amines are histamine H3modulators useful in the treatment of histamine H3receptor mediated diseases.

REFERENCES:
patent: 3714179 (1973-01-01), Tweit
patent: 3886160 (1975-05-01), Tweit
patent: 5030644 (1991-07-01), Baldwin et al.
patent: 5098900 (1992-03-01), Mutsukado et al.
patent: 5217986 (1993-06-01), Pomponi et al.
patent: 5352707 (1994-10-01), Pompni et al.
patent: 5464788 (1995-11-01), Bock et al.
patent: 5569659 (1996-10-01), Reitz
patent: 5681954 (1997-10-01), Yamamoto et al.
patent: 5756504 (1998-05-01), Bock et al.
patent: 5869479 (1999-02-01), Kreutner et al.
patent: 5883096 (1999-03-01), Lowe et al.
patent: 5889006 (1999-03-01), Lowe et al.
patent: 5900422 (1999-05-01), Ali
patent: 6596706 (2003-07-01), Kikuchi et al.
patent: 2004/0110746 (2004-06-01), Apodaca et al.
patent: 2007/0066821 (2007-03-01), Allison et al.
patent: 0186817 (1986-07-01), None
patent: 0624584 (1998-08-01), None
patent: 0978512 (2000-02-01), None
patent: 61267560 (1986-11-01), None
patent: 02306237 (1990-12-01), None
patent: HEI 10-59954 (1998-03-01), None
patent: WO 93/04684 (1993-03-01), None
patent: WO 9525443 (1995-09-01), None
patent: WO 9626196 (1996-08-01), None
patent: WO 97 30992 (1997-08-01), None
patent: WO 9805292 (1998-02-01), None
patent: WO 9924475 (1999-05-01), None
patent: WO 99/42458 (1999-08-01), None
patent: WO 02/12190 (2002-02-01), None
patent: WO 02/12214 (2002-02-01), None
patent: WO 02/20500 (2002-03-01), None
patent: WO 02/24695 (2002-03-01), None
patent: WO 02/062784 (2002-08-01), None
patent: WO 02/076925 (2002-10-01), None
patent: WO 03/004480 (2003-01-01), None
patent: WO 03/024928 (2003-03-01), None
patent: WO 03/024929 (2003-03-01), None
patent: WO 03/031432 (2003-04-01), None
patent: WO 03/050099 (2003-06-01), None
patent: WO 03/055866 (2003-07-01), None
patent: WO 03/064411 (2003-08-01), None
patent: WO 03066604 (2003-08-01), None
patent: WO 2004037801 (2004-05-01), None
patent: WO 2005/035534 (2005-04-01), None
patent: WO 2005/040144 (2005-05-01), None
patent: WO 2006/067401 (2006-06-01), None
patent: WO 2008015125 (2008-02-01), None
Aicher, T.D. et al.: “Secondary Amides of ®-3,3,3-Trifluoro-2-hydroxy-2-methylpropionis Acid as Inhibitors of Pyruvate Dehydrogenase Kinase”; J. Med. Chem. 2000, 43: 236-249.
Albengres, E. et al. Systemic Antifungal Agents. Drug Safety (Feb. 1998) 18(2):83-97.
Ali, S.M. et al. Design. Synthesis, and Structure-Activity Relationships of Acetylene-Based Histamine H3 Receptor Antagonists. J. Med. Chem. (1999) 42(5):903-909.
Anjaneyulu, B. et al. Synthesis of 14C-Labelled 1-Methanesulphonyl-3-(1-methyl-5-nitro-1H-imidazol-2-yl)-2-imidazolidinone, (Go 10213). J. Labelled Compd. Radiopharm. (1983) 20(8):951-961.
Apodaca, R. et al. A New Class of Diamine-Based Histamine H3 Receptor Antagonists: 4-(Aminoalkoxy)benzylamines. J. Med. Chem. (2003) 46(18):3938-3944.
Arrang, J.-M. et al. Auto-inhibition of Brain Histamine Release Mediated by a Novel Class (H3) of Histamine Receptor. Nature (Apr. 1983) 302:832-837.
Ash, A.S.F.; Schild, H.O. Receptors Mediating Some Actions of Histamine. Br. J. Pharmac. Chemother. (1966) 27:427-439.
Augustin, M. et al.: Zeitschrift fuer Chemie 1967, 7(10), 389.
Back, D.J.; Tjia, J.F. Inhibition of Tolbutamide Metabolism by Substituted Imidazole Drugs In Vivo: Evidence for a Structure-Activity Relationship. Br. J. Pharmacol. (1985) 85:121-126.
Barbier, A.J. et al.: “Acute wake-promoting actions of JNJ-5207852, a novel, diamine-based H3antagonist”; British J. of Pharmacology (2004) 143:649-661.
Barn, D.R. et al.: “Synthesis of an Array of Amides by Aluminum Chloride Assisted Cleavage of Resin-Bound Esters”, Tetrahedron Letters, Elsevier Science Publishers, Amsterdam, Netherlands, vol. 37(19): 3213-3216, Apr. 1996.
Barnes, J.C. et al. The Selective Histamine H3 Receptor Antagonist Thioperamide Improves Cognition and Enhances Hippocampal Acetylcholine Release In Vivo. Soc. Neurosci. Abstr. (1993) 19:1813.
Bioworld Today, Mar. 2, 1999, p. 3.
Black, J.W. et al. Definition and Antagonism of Histamine H2-Receptors. Nature (Apr. 1972) 236:385-390.
Celanire, S. et al.: “Histamine H3receptor antagonists reach out for the clinic”; DDT (Dec. 2005) 10(23/24):1613-1627.
Chen, Z.: “Effect of histamine H3-recepor anagonst clobenpropit on spatial memory of radial maze performance in rats”; Acta Pharmacol Sin (2000) 21(10): 905-910.
Ding, Y.-S. et al. Synthesis of High Specific Activity (+)- and (−)-6-[18F]Fluoronorepinephrine via the Nucleophilic Aromatic Substitution Reaction. J. Med. Chem. (1991) 34(2):767-771.
Erdelyi, M.; Gogoll, A. Rapid Homogeneous-Phase Sonogashira Coupling Reactions Using Controlled Microwave Heating. J. Org. Chem. (2001) 66(12):4165-4169.
Fox, G.B. et al.: “Effects of histamine H3receptor ligands GT-2331 and ciproxifan in a repeated acquisition avoidance response in the spontaneously hypertensive rat pup”; Behavioural Brain Research 131 (2002): 151-161.
Ganellin, C.R. et al. Synthesis of Potent Non-Imidazole Histamine H3-Receptor Antagonists. Arch. Pharm. Pharm. Med. Chem. (Weinheim, Ger.) (1998) 331:395-404.
Garbarg, M. et al. S-[2-(4-Imidazolyl)ethyl]isothiourea, a Highly Specific and Potent Histamine H3 Receptor Agonist. J. Pharmacol. Exp. Ther. (1992) 263(1):304-310.
Gillaspy, M.L. et al.: “A Simple Method for the Formation of Cyclopropylamines: The First Synthesis of Tricyclopropylamine”; Tetrahedron Letters (1995) 36(41): 7399-7402.
Gliatech Inc. Press Release Nov. 5, 1998.
Gonzalez, F. Garcia, et al. Synthesis of 3-aryl(alkyl)-4-(D-arabino-tetrahydroxybutyl)imidazolin-2-thiones, Carbohydrate Research, 22 (1972): 436-440.
Hancock, A.A.: “The challenge of drug discovery of a GPCR target: Analysis of preclinical pharmacology of histamine H3antagonists/inverse agonists”; Elsevier Biochem. Pharmacology (2006) 71: 1103-1113.
Hirt, R. et al.: Experientia 1961, 17, 418-20.
Ichinose, M.; Barnes, P.J. Histamine H3-Receptors Modulate Nonadrenergic Noncholinergic Neural Bronchoconstriction in Guinea-Pig In Vivo. Eur. J. Pharmacol. (1989) 174(1):49-55.
Iemura, R. et al. Synthesis of Benzimidazole Derivatives as Potential H1-Antihistaminic Agents. J. Heterocycl. Chem. (1987) 24:31-37.
Imamura, M. et al. Unmasking of Activated Histamine H3-Receptors in Myocardial Ischemia: Their Role as Regulators of Exocytotic Norepinephrine Release. J. Pharmacol. Exp. Ther. (1994) 271(3):1259-1266.
Ireland-Denny, L. et al.: “Species-related pharmacological heterogeneity of histamine H3receptors”; Elsevier European J. of Pharmacology 433 (2001): 141-150.
Iwata, R. et al. Synthesis of 3-[1H-Imidazole-4-yl]propyl 4-[18F]fluorobenzyl Ether ([18F]Fuoroproxyfan): A Potential Radioligand for Imaging Histamine H3 Receptors. J. Labelled Compd. Radiopharm. (2000) 43:873-882.
Jarosinski, M.A.; Anderson, W.K. Preparation of Noncondensed 2-Substituted 1-Methylimidazoles via Ipso Substitution Reaction on 2-Sulfinyl or 2-Sulfonyl Derivatives of 4,5-Disubstituted 1-Methylimidazoles. J. Org. Chem. (1991) 56(12):4058-4062.
Jones, R.G. Studies on Imidazoles. II. The Synthesis of 5-Imidazolecarboylates fromGlycine and Substituted Glycine Esters. J. Am. Chem. Soc. (1949) 71:644-647.
Jordaan, A., Arndt, R.R., The Synthesis of 1-Methyl-5-(α-indolyl)imidazole and 1-Methyl-2-ethylthiol-5-(α-indolyl)imidazole. Journal of Heterocyclic Chemistry 5(5), 723-5 (English) 1968.
Kapetanovic, I.M.; Kupferberg, H.J. Nafimidone, an Imidazole Anticonvulsant, and Its Metabolite as Potent Inhibitors of Microsomal Metabolism of Phenytoin and Carbamazepine. Drug Metab. Dispos. (1984) 12(5):560-564.
Korte, A. et al. Characterization and Tissue Distribution of H3 Histamine Receptors in Guinea Pigs by N alpha-Methylhistamine. Biochem. Biophys. Res. Commun. (May 1990) 168(3): 979-986.
Krause, M. et al. Medicinal Chemistry of Histamine H3 Receptor Agonists; In The Histamine H3 Receptor—A Target for New Drugs Leurs, R.; Timmerman, H. (Eds.) Elsevier (1998) 175-196.
Lamberti, C. et al.: “Ant

LandOfFree

Say what you really think

Search LandOfFree.com for the USA inventors and patents. Rate them and share your experience with other people.

Rating

Cyclopropyl amines as modulators of the histamine H 3 receptor does not yet have a rating. At this time, there are no reviews or comments for this patent.

If you have personal experience with Cyclopropyl amines as modulators of the histamine H 3 receptor, we encourage you to share that experience with our LandOfFree.com community. Your opinion is very important and Cyclopropyl amines as modulators of the histamine H 3 receptor will most certainly appreciate the feedback.

Rate now

     

Profile ID: LFUS-PAI-O-2748216

  Search
All data on this website is collected from public sources. Our data reflects the most accurate information available at the time of publication.