Cycloproply β-amino acid derivatives

Details Cycloproply β-amino acid derivatives Cycloproply β-amino acid derivatives

2006-04-18

2006-04-18

Price, Elvis O. (Department: 1621)

Organic compounds -- part of the class 532-570 series

Organic compounds

Carboxylic acids and salts thereof

Reexamination Certificate

active

07030267

ABSTRACT:
This invention relates to novel cyclopropyl β-amino acids derivatives of the formulawherein R1through R4are defined as in the specification, pharmaceutical compositions containing them and their use for the treatment of various central nervous system and other disorders. The cyclopropyl β-amino acids derivatives of this invention exhibit activity as alpha2delta ligands (α2δ ligands). Such compounds have affinity for the α2δ subunit of a calcium channel.

REFERENCES:
patent: 2002/0128185 (2002-09-01), Shih et al.
patent: 10059801 (1998-03-01), None
patent: WO 98 /08506 (1998-03-01), None
Caplus accession No. 1998:151085, abstract for Sugiyama et al, JP 10059801 (1998).
Caplus Accession No. 1992:105655 abstract for Ohno et al, Synlett (1991) 12, pp. 919-920.

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