Drug – bio-affecting and body treating compositions – Designated organic active ingredient containing – Nitrogen containing other than solely as a nitrogen in an...
Patent
1994-02-28
1995-05-16
O'Sullivan, Peter
Drug, bio-affecting and body treating compositions
Designated organic active ingredient containing
Nitrogen containing other than solely as a nitrogen in an...
514256, 514300, 514311, 514330, 514331, 514354, 514355, 514356, 514406, 514427, 514436, 514443, 514469, 514471, 514487, 514489, 514531, 514568, 514580, 514601, 514605, 514616, 514619, 514626, 544316, 544335, 546122, 546168, 546169, 546170, 546173, 546234, 546235, 546261, 546262, 546263, 546265, 5483335, 5483741, 548561, 549 58, 549 77, 549467, 549496, 560 39, 560 41, 560125, 562448, 562450, 562506, 564 46, 564 59, 564 91, 564152, 564155, 564164, 564168, A61K 31165, A61K 3118, C07C23720, C07C31118
Patent
active
054161177
ABSTRACT:
A novel cyclopropenone derivative (I) which possesses a potent inhibitory activity against thiol protease such as papain, cathepsin B, cathepsin H, cathepsin L, calpain or the like with excellent properties regarding oral absorbance, tissue transference and cell membrane permeability, and are clinically useful in the treatment of various diseases such as muscular dystrophy, amyotrophy. Also provided are a process for producing the compound (I) and a pharmaceutical composition containing the same.
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Ando Ryoichi
Morinaka Yasuhiro
Takahashi Chizuko
Tamao Yoshikuni
Tobe Akihiro
Mitsubishi Kasei Corporation
O'Sullivan Peter
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