Cyclopropane derivatives and use thereof as cell membrane mobili

Details Cyclopropane derivatives and use thereof as cell membrane mobili Cyclopropane derivatives and use thereof as cell membrane mobili

1975-07-22

1977-01-04

Rosen, Sam

Drug, bio-affecting and body treating compositions

Antigen, epitope, or other immunospecific immunoeffector

Recombinant or stably-transformed bacterium encoding one or...

195 18, 260468H, A61K 3125, C12K 900, C07C 6900

Patent

active

040014282

ABSTRACT:
Compounds capable of functioning as membrane mobility agents in plant and animal cells are described. These compounds have a structure represented by the formula ##STR1## in which A represents a hydrophilic chain; Z represents either an ester linkage ##STR2## an amide linkage ##STR3## or an ether linkage (--O--); R.sub.1 represents either a straight-chain alkyl group or a straight-chain alkyl group interrupted by one or more cyclopropyl groups; R.sub.2 and R.sub.3 each represent either hydrogen, lower alkyl, or a halogen group; and x represents an integer from 2 to 10.
The membrane mobility agents of the invention promote the lateral mobility through cell membranes of molecules ranging in size from phospholipids to surface antigens. They represent a new class of biologically active molecules which may be used to alter the mobility of membrane components in animal and plant cells to alter such cells in their response to external stimuli. Among their uses are altering the immunological response of lymphocytes; altering the pharmacological response of target cells; altering the biological properties of cancer cells; and fusing two or more cells to create a new hybrid cell containing the genetic information from the fused cells.

REFERENCES:
patent: 3737450 (1973-06-01), Henrick et al.
patent: 3792079 (1974-02-01), D'Orazio
patent: 3925461 (1975-12-01), Henrick et al.

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