Cyclopropane derivatives and method of preparing the same

Details Cyclopropane derivatives and method of preparing the same Cyclopropane derivatives and method of preparing the same

1995-03-30

1996-09-17

Trinh, Ba Kim

Organic compounds -- part of the class 532-570 series

Organic compounds

Heterocyclic carbon compounds containing a hetero ring...

549305, C07D30777

Patent

active

055569943

ABSTRACT:
A cyclopropane derivative represented by formula (I): ##STR1## wherein B represents a group of a purine derivative. In addition another aspect of the invention provides (3-oxa-2-oxobicyclo[3,1,0]hexan-1-yl)methanol and a method of preparing a cyclopropane derivative of formula (I) from this compound by replacing the hydroxyl group of the compound with a leaving group followed by reaction with a purine derivative.

REFERENCES:
Chemical Abstracts, vol. 121, No. 25, AN-300672t, Dec. 19, 1994, (JP-6-80670, Mar. 22, 1994).
The Journal of Organic Chemistry, vol. 58, No. 4, Feb. 12, 1993, pp. 879-886, Ari M. P. Koskimen, et al., "Intramolecular Cyclopropanation: Stereospecific Synthesis of (E)-And (Z)-1-Aminocyclopropane-1-Carboxylic Acids".
The Journal of Organic Chemistry, vol. 58, No. 14, Jul. 2, 1993, pp. 3767-3768, Kevin Burgess, et al., "Synthesis of a Valuable Cyclopropyl Chiron For Preparations of 2,3-Methanoamino Acids".
The Journal of Organic Chemistry, vol. 57, No. 22, Oct. 23, 1992, pp. 5931-5956, Kevin Burgess, et al., "Asymmetric Synthesis Of all Four Stereoisomers Of 2,3-Methanomethionine".
Tetrahedron Letters, vol. 30, No. 3, 1989, pp. 331-332, N. Oumar-Mahamat, et al., "Mn (III)-Mediated Radical Lactonisation Of Allylic Esters Of Acetoacetic And Malonic Acids".
Helvetica Chimica Acta, vol. 72, No. 6, 1989, pp. 1301-1310, Michael C. Pirrung, et al., "Synthesis And Study Of Racemic, (1R,2S)-, And (1S,2R)-1-Amino-2-(Hydroxymethyl)Cyclopropane-Carboxylic Acid".

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