Cyclopropane derivatives and anti-viral agent containing the sam

Drug – bio-affecting and body treating compositions – Designated organic active ingredient containing – Having -c- – wherein x is chalcogen – bonded directly to...

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544314, C07D23954, A61K 31505

Patent

active

054968240

ABSTRACT:
The present invention provides a pharmaceutical agent having a high pharmaceutical potency against varicella-zoster viruses and herpes simplex viruses, compositions containing the same, and methods for treating varicella-zoster viruses using the same.

REFERENCES:
patent: 5342840 (1994-08-01), Hatsuya et al.
Journal of Medicinal Chemistry, vol. 31, No. 12, Dec. 1988, Wallace T. Ashton, et al., "Synthesis and Antiherpetic Activity of (.+-.)-9-[[(Z)-2-(Hydroxymethyl)Cyclopropyl]Methyl]Guanine And Related Compounds", pp. 2304-2315.
Journal of Medicinal Chemistry, vol. 35, No. 10, May 15, 1992, William A. Slusarchyk, et al., "Synthesis And Antiviral of 1-Cyclobutyl-5(2-Bromovinyl)Uracil Nucleoside Analogues And Related Compounds", pp. 1799-1806.
Chung K. Chu et al., "Chemistry and Antiviral Activities of Acyclonucleosides", J. Heterocyclic Chem., Mar.-Apr. 1986, 23-289-319.

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