Cyclophosphamide monohydrate and lactose

Details Cyclophosphamide monohydrate and lactose Cyclophosphamide monohydrate and lactose

1993-05-20

1994-08-09

Hook, Gregory

Drug, bio-affecting and body treating compositions

Designated organic active ingredient containing

Carbohydrate doai

514110, 514960, 514777, A61K 31715, A61K 3166, A61K 4700

Patent

active

053366697

ABSTRACT:
A parmaceutical preparation consisting essentially of a lyophilized cake of cyclophosphamide monohydrate and lactose prepared by the process of freezing cyclophosphamide, lactose and water, lyophilizing part of the water, obtaining and melting a supersaturated cyclophosphamide-lactose solution, precipitating cyclophosphamide as a hydrated polymorph, refreezing the solution and lyophilizing the water not bound to cyclophosphamide or lactose.

REFERENCES:
patent: 4537883 (1985-08-01), Alexander
patent: 4659699 (1987-04-01), Francis
patent: 5036060 (1991-07-01), Alam
Kovalcik et al "The Stability of Cyclophosphamide . . ." Chem Abstract 108(4): 210088; 1988.

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