Cyclophosphamide analogs useful as anti-tumor agents

Drug – bio-affecting and body treating compositions – Designated organic active ingredient containing – Phosphorus containing other than solely as part of an...

Patent

Rate now

  [ 0.00 ] – not rated yet Voters 0   Comments 0

Details

514 82, 514 85, 514 86, 514 89, 514 91, 514 92, 514 94, 514 95, 514 96, 514 99, 514100, 514110, 544232, 546 22, 546 23, 548112, 548113, 548413, 548414, 549 6, 549218, 549220, C07F 96584, A61K 31675

Patent

active

051909294

ABSTRACT:
Cyclophosphamides possessing anti-tumor activity and having the formula ##STR1## and salts thereof; wherein R is lower alkyl, aryl, aryl-lower alkyl or a nitrogen, sulfur or oxygen containing heterocyclic or heterocyclic lower alkyl, and

REFERENCES:
patent: 3808297 (1974-04-01), Takamizawa et al.
patent: 4623742 (1986-11-01), Schaeffler
Pazdur, Proc. Am. Soc. Clin. Oncology 3, p. 219 (1984).
Martin et al, Cancer Research 49, 2189 (1986).
Farmer, Chem-Biol. Interactions 18, 47-57 (1977).
Cox, I Adv. Mass Spectrum. Biochem & Medicine, 1, 59-71 (1976).
Cox II Biochem. Pharmacol 24 p. 599 (1975).
Shih, Heterocycles 24(6) 1599-603 (1986).
Cyclophosphamide, Merck Index, p. 2736.
Foster, Journal of Pharmaceutical Sciences, 67, 709-710 (1978).
Sakuri, Cancer Chemother. Cent., Japan Found. Cancer Res. 272-281 (1978).
Arndt, et al., Cancer Research, 47, 5932-5934 (1987).
Friedman, et al., Cancer Treatment Reports, 60, 337-345 (1976).
Carter, Cancer Chemother Pharmacol, 1, 15-24 (1978).
Camerman, et al., J. Med. Chem., 26, 679-683 (1983).
Foster, et al., J. Med. Chem., 24, 1399-1403 (1981).
Takamizawa, et al., Journal of Medicinal Chemistry, 21, 208-214 (1978).
White, et al., JACS, 101, 1937-1942 (1978).
Gurtoo, et al., Journal of Biological Chemistry, 256, 11691-11701 (1976).
Boyd, et al., J. Med. Chem., 23, 372-375 (1980).
Ludeman, et al., Drugs, Exp. Clin. Res., XII, 527-532 (1986).
Ludeman, et al., J. Med. Chem., 29, 716-727 (1980).
Arnold, et al., Arzneim, Forsch., 11, 143 (1961).
Shih, et al., Heterocycles, 9, 1277 (1978).
Shih, et al., Heterocycles, 24, 1599 (1986).
Shih, et al., Heterocycles, 22, 2799 (1984).
Ludeman et al, "J. Med. Chem.", vol. 22, No. 2, (1979), pp. 151-158.

LandOfFree

Say what you really think

Search LandOfFree.com for the USA inventors and patents. Rate them and share your experience with other people.

Rating

Cyclophosphamide analogs useful as anti-tumor agents does not yet have a rating. At this time, there are no reviews or comments for this patent.

If you have personal experience with Cyclophosphamide analogs useful as anti-tumor agents, we encourage you to share that experience with our LandOfFree.com community. Your opinion is very important and Cyclophosphamide analogs useful as anti-tumor agents will most certainly appreciate the feedback.

Rate now

     

Profile ID: LFUS-PAI-O-126601

  Search
All data on this website is collected from public sources. Our data reflects the most accurate information available at the time of publication.