Drug – bio-affecting and body treating compositions – Designated organic active ingredient containing – Phosphorus containing other than solely as part of an...
Patent
1991-05-17
1993-12-07
Hollrah, Glennon H.
Drug, bio-affecting and body treating compositions
Designated organic active ingredient containing
Phosphorus containing other than solely as part of an...
514960, 562575, A61K 3166
Patent
active
052683680
ABSTRACT:
A stable rapidly dissolving lyophilized composition of cyclophosphamide and an amino acid selected from the group consisting of glycine, valine and serine is provided which contains an amount of water which is equimolar to the amount of amino acid and the amount of cyclophosphamide in said composition; the composition is preferably prepared from a solution containing at least 2% (W/V) of the amino acid and having a pH in the range of 5.0 to 7.0.
REFERENCES:
patent: 4537883 (1985-08-01), Alexander et al.
patent: 5066647 (1991-11-01), Palepu et al.
Osswald, "Potentiated Chemotherapeutic Activity . . . " Arzneimihelforschung. 25(10):1608-09, Oct. 1975.
European search report, EP304223, (Mar. 1991).
Burn Brian M.
Erbamont Inc.
Hollrah Glennon H.
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