Drug – bio-affecting and body treating compositions – Designated organic active ingredient containing – Phosphorus containing other than solely as part of an...
Patent
1988-04-04
1989-11-07
Goldberg, Jerome D.
Drug, bio-affecting and body treating compositions
Designated organic active ingredient containing
Phosphorus containing other than solely as part of an...
A61K 3166
Patent
active
048792861
ABSTRACT:
A storage-stable liquid oncolytic formulation of cyclophosphamide for parenteral administration is presented. Currently utilized lyophilized formulations have inherent diseconomies and increased hazard is associated with reconstitution. The liquid formulations of the present invention comprise a solution of cyclophosphamide with an organic polyol as cosolvent, which provide enhanced shelf-life and greater ease of administration. The polyol is either propylene glycol, polyethylene glycol or glyerol. The solution of cyclophosphamide is either aqueous, or in the case of propylene glycol may constitute 10-30% by weight of an alcohol.
REFERENCES:
patent: 3018302 (1962-01-01), Arnold et al.
patent: 3732340 (1973-05-01), Arnold et al.
patent: 4537883 (1987-09-01), Arnold et al.
Alam Abu S.
Kapoor John N.
Koziol Kenneth J.
Goldberg Jerome D.
Lyphomed, Inc.
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