Cyclophilin

Details Cyclophilin Cyclophilin

1985-05-03

1988-02-02

Kight, John

Chemistry: natural resins or derivatives; peptides or proteins;

Proteins, i.e., more than 100 amino acid residues

Separation or purification

530413, 530415, 530417, 530350, 530324, 530317, 530350, C07K 320

Patent

active

047229993

ABSTRACT:
Homogeneous cyclophilin, a soluble binding protein, having a specific binding activity of above 50 ug cyclosporin A per mg protein and a molecular weight of about 17,600 daltons, reversibly binds immunosuppressants or antibodies thereto such as cyclosporin or anti-cyclophilin. It is isolated from thecytosol of several different mammalian tissues and can be used in various diagnostic and purifications procedures.

REFERENCES:
Colombani et al., "Cyclosporin A Binding to Calmodulin: A Possible Site of Action on T Lymphocytes", Science 228, (1985), 337-339.
Colombani et al., "Calmodulin, Cyclophilin, and Cyclosporin A", Science 233, (1986), 987-988.
Merker et al., J. Immunol, 132(6), Jun. 1984, pp. 3064-3070.
Ryffel et al., Immunology, 41, 1980, p. 913.
Ryffel et al., J. Immunol, 129, 1982, p. 1978.
M. Merker, J. Rice, B. Schweitzer and R. E. Handschumacher, "Cyclosporine Binding Component in BW5147 Lymphoblasts and Normal Lymphoid Tissue", Transplantation Proceedings, vol. XV, No. 4, Suppl. 1, (Dec.) 1983.
Handschumacher et al., Cyclophilin; A Specific Cytosolic Binding Protein for Cyclosporin A., Science 226 (4674), 1984, pp. 544-547.

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