Cyclopentyl derivatives

Details Cyclopentyl derivatives Cyclopentyl derivatives

2007-09-04

2007-09-04

Kumar, Shailendra (Department: 1621)

Organic compounds -- part of the class 532-570 series

Organic compounds

Amino nitrogen containing

C514S619000, C514S620000

Reexamination Certificate

active

10580366

ABSTRACT:
This invention is related to novel cyclopentyl derivatives of the following general Formula (I), wherein X is methylene, oxygen, sulphur or a NR7group; R1is a straight or branched C1-C8alkyl or C3-C8alkenylene or C3-C8alkynylene chain, optionally substituted with CF3, phenyl, phenoxy or naphthyl, the aromatic rings optionally substituted by one or more C1-C4alkyl, halogens, trifluoromethyl, hydroxy or C1-C4alkoxy groups; R2, R3are independently hydrogen, a C1-C3alkyl chain, halogen, trifluoromethyl, hydroxy or C1-C4alkoxy groups; R4, R5,R6, R7are independently hydrogen or C1-C6alkyl; and the pharmaceutically acceptable salts thereof that are active as sodium and/or calcium channel modulators and therefor useful in preventing, alleviating and curing a wide range of pathologies, including, but not limited to, neurological, psychiatric, cardiovascular, inflammatory, ophthalmic, urologic, metabolic and gastrointestinal diseases, where the above mechanisms have been described as playing a pathological role.

REFERENCES:
patent: 26 24 290 (1977-04-01), None
patent: WO99/35125 (1999-07-01), None
patent: WO 03/057147 (2003-07-01), None

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