Cyclopentenone derivative

Details Cyclopentenone derivative Cyclopentenone derivative

1999-07-21

2000-10-24

Geist, Gary

Drug, bio-affecting and body treating compositions

Designated organic active ingredient containing

Ester doai

514533, 560 84, 560193, A61K 31235, C07C 6976, C07C 6952

Patent

active

061368547

ABSTRACT:
Cyclopentenone derivative having a structure of 5-(R.sub.1 COO--)-4-(R.sub.2 COO--)--substituted 2-cyclopenten-1-one (R.sub.1 and R.sub.2 are some or different and each is alkyl group, alkenyl group or aryl group) or an optically active substance thereof; a method for the manufacture of the cyclopentenone derivative by the reaction of 4,5-dihydroxy-2-cyclopenten-1-one with the corresponding carboxylic acid or a reactive derivative thereof; and anticancer agent, apoptosis-inducing agent and antibacterial agent containing said derivative.

REFERENCES:
Ahmad, T., On the formation of reductiv acid from pentoses or hexuronic acids Carbohydrates Res., vol. 247, pp. 217-222, 1993.
Amos B. Smith, "Stereocontrolled total synthesis of (.+-.)-pentenomycins. I-III, their epimers, and dehydropentenomycin I," J. Organ. Chem., vol. 47, No. 10, pp. 1855-1869 (1982).
International Preliminary Examination Report for International Application No. PCT/JP98/00817, Feb. 25, 1999.

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