Cyclopentene derivatives useful as antagonists of the motilin re

Details Cyclopentene derivatives useful as antagonists of the motilin re Cyclopentene derivatives useful as antagonists of the motilin re

1998-10-26

1999-10-26

Ramsuer, Robert W.

Drug, bio-affecting and body treating compositions

Designated organic active ingredient containing

Heterocyclic carbon compounds containing a hetero ring...

514617, 514628, 544 86, 544131, 544146, 544148, 544168, 544169, 544159, 544167, 544165, 546190, 546234, 548574, 560 45, 564154, 564157, 564158, 564185, 564211, 564212, 564213, A61K 3116, A61K 31535, C07C23334, C07D29514

Patent

active

059729392

ABSTRACT:
The compounds of formula I are useful in treating gastrointestinal disorders associated with antagonizing the motilin receptor disorders. The compounds compete with erythromycin and motilin for the motilin receptor. In addition the compounds are antagonists of the contractile smooth muscle response to those ligands.

REFERENCES:
patent: 4935053 (1990-06-01), Burgoyne et al.
Beckert et al, Chemical Abstracts, vol. 128, No. 34728, 1997.

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