Cyclopentanone derivatives

Details Cyclopentanone derivatives Cyclopentanone derivatives

1976-07-13

1978-03-21

Gerstl, Robert

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424283, 424305, 424317, 2603475, 2603458P, 2603459P, 26034818, 260408, 2604109R, 260413, 260447, 260448R, 2605011, 26034858, 260514D, 260514K, 260601H, 560121, 560122, 560126, 560174, 560183, C07C 6974, C07C 704, C07C17700

Patent

active

RE0295876

ABSTRACT:
Novel prostanoic acid derivatives of the formula ##STR1## wherein R is selected from the group consisting of hydrogen and alkyl of 1 to 7 carbon atoms, R.sub.1 is selected from the group consisting of hydrogen and carbalkoxy of 1 to 7 alkyl carbon atoms, R.sub.2 is selected from the group consisting of hydrogen, carboxy and carbalkoxy of 1 to 7 alkyl carbon atoms, R.sub.3 is selected from the group consisting of hydrogen and .alpha.-tetrahydropyranyl and at least one of R.sub.1, R.sub.2 and R.sub.3 is other than hydrogen, m is 3, 4 or 5 and n is 2, 3 or 4 with the proviso that when R.sub.1 is carbalkoxy, R is alkyl of 1 to 7 carbon atoms, R.sub.2 is hydrogen and R.sub.3 is .alpha.-tetrahydropyranyl; when R.sub.2 is carbalkoxy, R is alkyl of 1 to 7 carbon atoms, R.sub.1 is hydrogen and R.sub.3 is .alpha.-tetrahydropyranyl and when R.sub.2 is carboxy, R and R.sub.1 are hydrogen and R.sub.3 is .alpha.-tetrahydropyranyl, which possess the physiological activity of prostaglandins [ , and salts thereof when R, R.sub.1, R.sub.2 and R.sub.3 are hydrogen, with non-toxic, pharmaceutically acceptable bases] and their preparation.

REFERENCES:
patent: 3678092 (1972-07-01), Finch
patent: 3736319 (1973-05-01), Martel et al.
patent: 3801623 (1974-04-01), Martel et al.
patent: 3870710 (1975-03-01), Martel et al.
patent: 3870711 (1975-03-01), Martel et al.
Martel, Tetrahedron Letters, 1972, pp. 1491 to 1496.
Mayer, Newer Methods of Preparative Organic Chemistry, vol. 2, pp. 101-108 (1963).
Marvel et al., J. Am. Chem. Soc. 79 (4990) 19657.

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