Cyclopentano (h) or (f) 1,2,3,4-tetrahydroisoquinolines

Details Cyclopentano (h) or (f) 1,2,3,4-tetrahydroisoquinolines Cyclopentano (h) or (f) 1,2,3,4-tetrahydroisoquinolines

1974-03-28

1976-06-15

Rush, Raymond V.

Chemistry of carbon compounds

Miscellaneous organic carbon compounds

C-metal

260283SY, 260289C, 260566R, 2605708R, 260613D, 424258, C07D21700

Patent

active

039637239

ABSTRACT:
Provided are novel cyclopentano-1,2,3,4-tetrahydroisoquinolines of the formula ##SPC1##
Wherein R and R.sub.1 are the same or different lower alkyl groups, R.sub.2 is hydrogen or a lower alkyl group, m is an integer from 1 to 2, n is an integer from 1 to 2 and m + n equals 3, and acid addition salts thereof, processes for making the compounds and pharmaceutical compositions containing one or more of the compounds useful as hypotensive agents. Also provided are intermediates of the formula ##SPC2##
Wherein R and R.sub.1 are the same or different lower alkyl groups and R.sub.3 is hydrogen, CHO--, ##EQU1## wherein R.sub.2 is hydrogen or a lower alkyl group.

REFERENCES:
patent: 3541158 (1970-11-01), Shulgin
Brown et al., "J. Chem. Soc.," pp. 4295-4298 (1961).

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