Cyclopentane heptenylnitro and heptanylnitro-2-aliphatic or aryl

Details Cyclopentane heptenylnitro and heptanylnitro-2-aliphatic or aryl Cyclopentane heptenylnitro and heptanylnitro-2-aliphatic or aryl

1992-10-28

1994-07-12

Gerstl, Robert

Drug, bio-affecting and body treating compositions

Designated organic active ingredient containing

C-o-group doai

568704, C07C20503, A01K 31557

Patent

active

053289331

ABSTRACT:
The present invention relates to cyclopentane heptenylnitro and heptanylnitro-2-aliphatic or arylaliphatic derivatives. In particular, heptenylnitrate and heptanylnitrate 2-aliphatic or arylaliphatic derivatives, substituted at the 3 and/or 5 position of the cyclopentane ring with radicals selected from the group consisting of hydroxy, alkylcarboxy and mixtures thereof, are disclosed. These compounds are useful as ocular hypotensives.

REFERENCES:
patent: 4599353 (1986-07-01), Bito
patent: 4994274 (1991-02-01), Chan et al.
patent: 5028624 (1991-07-01), Chan et al.
patent: 5034413 (1991-07-01), Chan et al.
Starr, M. S., "Further Studies on the Effect of Prostaglandin on Intraocular Pressure in the Rabbit," Exp. Eye. Res. (1971), pp. 170-177.
Bito, L. Z., "Prostaglandins and Related Compounds as Potential Ocular Therapeutic Agents," Biological Protection with Prostaglandins, Cohen, M. ed., Boca Raton, Fla., CRC Press Inc., 1985, pp. 231-252.
Bito, L. Z., "Prostaglandins, Other Eicosanoids, and Their Derivatives as Potential Antiglaucoma Agents," Applied Pharmacology in the Medical Treatment of Glaucomas, Drance, S. M. and Neufield, A. H. eds., New York, Grune & Stratton, 1984, pp. 477-505.
Nilsson, et al., Invest. Ophthalmol. Vis. Sci. 28 (suppl), 284 (1987).
Bito, L. Z., "Prostaglandins, Old Concepts and New Perspectives," Arch. Ophthalmol. 105, 1036 (1987).
Siebold, et al., "Esterified prostaglandin shows `potent` promise," Prodrug 5, 3 (1989).

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