Cyclopentane heptanoic or heptenoic acid, 2-arylalkyl or arylalk

Details Cyclopentane heptanoic or heptenoic acid, 2-arylalkyl or arylalk Cyclopentane heptanoic or heptenoic acid, 2-arylalkyl or arylalk

1993-10-28

1996-01-23

Fay, Zohreh

Drug, bio-affecting and body treating compositions

Designated organic active ingredient containing

Ester doai

514573, 514724, 514913, A61K 31215, A61K 3119, A61K 31045

Patent

active

054865409

ABSTRACT:
The present invention provides therapeutic agents comprising cyclopentane heptane or heptenoic acid, 2 arylalkyl or arylalkenyl and derivatives thereof, wherein the carboxylic acid of the parent compound is converted to a hydroxyl or ester group. These therapeutic agents are potent ocular hypotensives as well as having other therapeutic uses.

REFERENCES:
patent: 4494274 (1991-02-01), Chan et al.
patent: 4599353 (1991-07-01), Bito
patent: 5034413 (1991-07-01), Chan et al.
Caton et al, "Synthesis of Some Novel 11-Deoxyprostaglandins", Chemistry, Biochemistry & Pharmacological Activity of Prostanoids, 1978, pp. 27-38.
Chemical Abstracts, vol. 90, Columbus, Ohio, No. 103514h 1979.
Chemical Abstracts, vol. 90, Columbus, Ohio, No. 103508j 1979.
Bito, L. Z., "Prostaglandins and Related Compunds as Potential Ocular Therapeutic Agents," Biological Protection with Prostaglandins, Cohen, M. M., ed., Boca Raton, Fla., CRC Press, Inc., 1985, pp. 231-252.
Bito, L. Z., "Prostaglandins, Other Eicosanoids, and Their Derivatives as Potential Antiglaucoma Agents," Applied Pharmacology in the Medical Treatment of Glaucomas Drance, S. M. and Neufeld, A. H. eds., New York, Grune & Stratton, 1984, pp. 477-505.
Nilsson, et al., "PGF.sub.2.alpha. Increases Uveoscleral Outflow," Invest. Ophthalmol. Vis. Sci. (suppl), 284, 1987.
Siebold, et. al., "Esterified prostaglandin shows `potent` promise," Prodrug 53, 1989.
Bito, L. Z., "Prostaglandins, Old Concepts and New Perspectives," Arch. Ophthalmol. 105, 1036, 1987.

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