Cyclopentane heptan(ene)oic acid, 2-heteroarylalkenyl derivative

Details Cyclopentane heptan(ene)oic acid, 2-heteroarylalkenyl derivative Cyclopentane heptan(ene)oic acid, 2-heteroarylalkenyl derivative

1999-04-20

2000-03-14

Lambkin, Deborah C.

Drug, bio-affecting and body treating compositions

Designated organic active ingredient containing

Having -c-, wherein x is chalcogen, bonded directly to...

514461, A61K 3138, A61K 3134

Patent

active

060373644

ABSTRACT:
The invention relates to the use of derivatives of F-type prostaglandins as ocular hypotensives. The PGF derivatives used in accordance with the invention are represented by the following formula I: ##STR1## wherein wavy line attachments indicate either the alpha (.alpha.) or beta (.beta.) configuration; dashed bonds represent a double bond, or a single bond, R is a substituted heteroaryl radical, R.sup.1 is hydrogen or a lower alkyl radical having up to six carbon atoms, X is selected from the group consisting of --OR.sup.1 and --N(R.sup.1).sub.2, Y is .dbd.O or represents 2 hydrogen radicals. Certain of the compounds represented by Formula I comprise another aspect of the present invention.

REFERENCES:
patent: 5296504 (1994-03-01), Stjernschantz et al.
patent: 5321128 (1994-06-01), Stjernschantz et al.
patent: 5422368 (1995-06-01), Stjernschantz et al.
patent: 5422369 (1995-06-01), Stjernschantz et al.
C. Liljebris et al, Derivatives of 17-Phenyl-18, 19, 20-trinorprostaglandin F-2-alpha Isopropyl Esters: Potential Antiglaucoma Agents, J. Med. Chem. vol. 38, No. 2, Jan. 20, 1995, pp. 289-304.

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