Cyclopentane heptan(ene) oic acid, 2-heteroarylalkenyl derivativ

Details Cyclopentane heptan(ene) oic acid, 2-heteroarylalkenyl derivativ Cyclopentane heptan(ene) oic acid, 2-heteroarylalkenyl derivativ

1998-11-03

1999-10-26

Lambkin, Deborah C.

Drug, bio-affecting and body treating compositions

Designated organic active ingredient containing

Having -c-, wherein x is chalcogen, bonded directly to...

514461, 514365, 514374, 549 78, 549 75, 549 79, 549 77, 549497, 549499, 549502, A61K 3138, A61K 31425, C07D33316, C07D30702

Patent

active

059729910

ABSTRACT:
The invention relates to the use of derivatives of F-type prostaglandins as ocular hypotensives. The PGF derivatives used in accordance with the invention are represented by the following formula I: ##STR1## wherein wavy line attachments indicate either the alpha (.alpha.) or beta (.beta.) configuration; hatched segments indicate .alpha. configuration, solid triangles are used to indicate .beta. configuration, dashed bonds represent a double bond, or a single bond, R is a substituted heteroaryl radical, R.sup.1 is hydrogen or a lower alkyl radical having up to six carbon atoms, X is selected from the group consisting of --OR.sup.1 and --N(R.sup.1).sub.2, Y is =O or represents 2 hydrogen radicals. Certain of the compounds represented by Formula I comprise another aspect of the present invention.

REFERENCES:
patent: 5352708 (1994-10-01), Woodward et al.
patent: 5607978 (1997-03-01), Woodward et al.
patent: 5688819 (1997-11-01), Woodward et al.
patent: 5834498 (1998-11-01), Burk

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