Cyclopentane(ene) heptanoic or cyclopentane(ene) heptenoic acid,

Details Cyclopentane(ene) heptanoic or cyclopentane(ene) heptenoic acid, Cyclopentane(ene) heptanoic or cyclopentane(ene) heptenoic acid,

1993-08-17

1995-02-07

O'Sullivan, Peter

Drug, bio-affecting and body treating compositions

Designated organic active ingredient containing

Ester doai

514183, 514357, 514438, 514471, 514523, 514562, 514604, 514913, 546338, 549 75, 549491, 552 10, 558408, 560 12, 560121, 560122, 562430, 562503, 564 80, 564 90, 564 93, A61K 31215, A61K 31195, C07C 6974, C07C40500

Patent

active

053876083

ABSTRACT:
The present invention relates to cyclopentane heptanoic or cyclopentane heptenoic acid, 2-hydrocarbyl sulfonamidomethyl, and derivatives thereof, useful as therapeutic agents. In particular, the therapeutic agents of this invention are useful as ocular hypotensives.

REFERENCES:
patent: 4599353 (1986-07-01), Bito
patent: 4994274 (1991-02-01), Chan et al.
patent: 5034413 (1991-07-01), Chan et al.
Bito, L. Z., "Prostaglandins and Related Compounds as Potential Ocular Therapeutic Agents," Biological Protection with Prostaglandins, Cohen, M. M., ed., Boca Raton, Fla., CRC Press, Inc., 1985, pp. 231-252.
Bito, L. Z., "Prostaglandins, Other Eicosanoids, and Their Derivatives as Potential Antiglaucoma Agents," Applied Pharmacology in the Medical Treatment of Glaucomas Drance, S. M. and Neufeld, A. H. eds., New York, Grune & Stratton, 1984, pp. 477-505.
Nilsson, et al., "PGF.sub.2.alpha. Increases Uveoscleral Outflow," Invest. Ophthalmol. Vis. Sci. (suppl), 284, 1987.
Siebold, et al., "Esterified prostaglandin shows `potent` promise," Prodrug 5 3, 1989.
Bito, L. Z., "Prostaglandins, Old Concepts and New Perspectives," Arch. Ophthalmol. 105, p. 1036, 1987.

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