Organic compounds -- part of the class 532-570 series – Organic compounds – Four or more ring nitrogens in the bicyclo ring system
Patent
1979-08-02
1980-09-02
Jiles, Henry R.
Organic compounds -- part of the class 532-570 series
Organic compounds
Four or more ring nitrogens in the bicyclo ring system
544139, 544405, C07D41306, C07D40304
Patent
active
042207630
ABSTRACT:
2,4,5,6-Tetrahydrocyclopenta[c]pyrrole-4-carboxamide and 4-thiocarboxamide derivatives useful as antisecretory and anti-ulcer agents are prepared by hydrolysis or thiohydrolysis of the corresponding 2,4,5,6-tetrahydrocyclopenta[c]pyrrole-4-carbonitriles or, in the case of the thiocarboxamides, by reaction of the 4-carboxamide with phosphorus pentasulfide.
REFERENCES:
Volz et al., "Tetrahedron Letters", No. 47, pp. 4111-4114 (1969).
Berger et al., "J. Org. Chem.", vol. 35, No. 9 (1970), pp. 3122-3125.
Bell Malcolm R.
Oesterlin Rudolf
Jiles Henry R.
Ramsuer R. W.
Sterling Drug Inc.
Webb William G.
Wyatt B. Woodrow
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