Drug – bio-affecting and body treating compositions – Designated organic active ingredient containing – Heterocyclic carbon compounds containing a hetero ring...
Reexamination Certificate
2011-06-21
2011-06-21
Aulakh, Charanjit S (Department: 1625)
Drug, bio-affecting and body treating compositions
Designated organic active ingredient containing
Heterocyclic carbon compounds containing a hetero ring...
C540S521000, C540S578000
Reexamination Certificate
active
07964590
ABSTRACT:
The present invention relates to steroidal alkaloids useful in the treatment of hedgehog pathway related disorders, particularly cancer.
REFERENCES:
patent: 6238876 (2001-05-01), Altaba
patent: 6291516 (2001-09-01), Dudek et al.
patent: 6432970 (2002-08-01), Beachy et al.
patent: 6867216 (2005-03-01), Beachy et al.
patent: 7098196 (2006-08-01), Beachy et al.
patent: 7230004 (2007-06-01), Adams et al.
patent: 7291626 (2007-11-01), Beachy et al.
patent: 7407967 (2008-08-01), Adams et al.
patent: 7648994 (2010-01-01), Castro et al.
patent: 7812164 (2010-10-01), Austad et al.
patent: 2003/0114393 (2003-06-01), Liscovitch et al.
patent: 2004/0072913 (2004-04-01), Tas et al.
patent: 2004/0072914 (2004-04-01), Tas et al.
patent: 2004/0110663 (2004-06-01), Dudek et al.
patent: 2004/0126359 (2004-07-01), Lamb et al.
patent: 2004/0127474 (2004-07-01), Dudek et al.
patent: 2006/0094660 (2006-05-01), Thomson
patent: 2006/0128639 (2006-06-01), Beachy
patent: 2006/0142245 (2006-06-01), Beachy et al.
patent: 2007/0009530 (2007-01-01), Altaba et al.
patent: 2007/0231828 (2007-10-01), Beachy et al.
patent: 2007/0281040 (2007-12-01), Weichselbaum et al.
patent: 2008/0019961 (2008-01-01), Wicha et al.
patent: 2008/0057071 (2008-03-01), Watkins et al.
patent: 2008/0058298 (2008-03-01), Beachy et al.
patent: 2008/0095761 (2008-04-01), Beachy et al.
patent: 2008/0118493 (2008-05-01), Beachy et al.
patent: 2009/0012109 (2009-01-01), Austad et al.
patent: 2009/0216022 (2009-08-01), Austad et al.
patent: 2010/0144775 (2010-06-01), Castro et al.
patent: WO-95/18856 (1995-07-01), None
patent: WO-96/17924 (1996-06-01), None
patent: WO-00/41545 (2000-07-01), None
patent: WO-01/27135 (2001-04-01), None
patent: WO-01/49279 (2001-07-01), None
patent: WO-02/30462 (2002-04-01), None
patent: WO-02/078703 (2002-10-01), None
patent: WO-02/078704 (2002-10-01), None
patent: WO-03/088964 (2003-10-01), None
patent: WO-2005/013800 (2005-02-01), None
patent: WO-2005/032343 (2005-04-01), None
patent: WO-2005/042700 (2005-05-01), None
patent: WO-2006/026430 (2006-03-01), None
patent: WO-2007/123511 (2007-11-01), None
patent: WO-2008/083248 (2008-07-01), None
patent: WO-2008/083252 (2008-07-01), None
patent: WO-2008/089123 (2008-07-01), None
Alexandre et al., “Transcriptional Activation of Hedgehog Target Genes inDrosophilais Mediated Directly by the Cubitus Interruptus Protein, a Member of the GLI Family of Zinc Finger DNA-Binding Proteins” Genes and Development (1996) 10:2003-2013.
Bale and Yu, “The Hedgehog Pathway and Basal Cell Carcinomas” Human Molecular Genetics (2001) 10:757-762.
Belloni et al., “Identification of Sonic Hedgehog as a Candidate Gene Responsible for Holoprosencephaly” Nature Genetics (1996) 14:353-356.
Berge et al.,“Pharmaceutical Salts” Journal of Pharmaceutical Sciences (1977) 66:1-19.
Berman et al., “Widespread Requirement for Hedgehog Ligand Stimulation in Growth of Digestive Tract Tumours” Nature (2003) 425:846-851.
Berman et al., “Medulloblastoma Growth Inhibition by Hedgehog Pathway Blockade” Science (2002) 297:1559-1561.
Chen et al., “Inhibition of Hedgehog Signaling by Direct Binding of Cyclopamine to Smoothened” Genes and Development (2002) 16:2743-2748.
Cooper et al., “Teratogen-Mediated Inhibition of Target Tissue Response to Shh Signaling” Science (1998) 280:1603-1607.
Fan et al., “Hedgehog Singaling Promotes Prostate Zenograft Tumor Growth” Endocrinology (2004) 145:3961-3970.
Karhadker et al., “Hedgehog Signalling in Prostate Regeneration, Neoplasia and Metastasis” Nature (2004) 431:707-712.
Kitajima et al., “Steroid Alkaloids of Fresh Bulbs ofFritillaria thunbergiiMiq. and of Crude Drug “BAI-MO” Prepared Therefrom” Heterocycles (1981) 15:791-796.
Kubo et al., “Hedgehog Signaling Pathway is a New Therapeutic Target for Patients with Breast Cancer” Cancer Research (2004) 64:6071-6074.
Lee et al., “Development of an Enzyme-linked Immunosorbent Assay for the Veratrum Plant Teratogens: Cyclopamine and Jervine” Journal of Agricultural and Food Chemistry (2003) 51:582-586.
Lewis and Veltmaat, “Next Stop, the Twilight Zone: Hedgehog Network Regulation of Mammary Gland Development” Journal of Mammary Gland Biology and Neoplasia (2004) 2:165-181.
Ma et al., “Frequent activation of the hedgehog pathway in advanced gastric adenocarcinomas” Carcinogenesis (2005) 10:1698-1705.
Mazur et al. “Azasteroids III. 3-Aza-A-Homo Androgens” J. Org. Chem. (1963) 28:248-250.
Nakamura et al., “Induction of Osteogenic Differentiation by Hedgehog Proteins” Biochemical and Biophysical Research Communications (1997) 237:465-469.
Oka and Hara, “Regiospecific Beckmann Rearrangement of 3-Oxo-4-ene Steroid Oximes” J. Org. Chem. (1978) 43:3790-3791.
Oka and Hara, “Synthesis of A-Azasteroids by the Use of Specific Beckmann Rearrangement” Chemistry and Industry (1969) 168-170.
Patil et al., “Hedgehog Signaling in Human Hepatocellular Carcinoma” Cancer Biology & Therapy (2006) 5:111-117.
Peacock et al., “Hedgehog Signaling Maintains a Tumor Stem Cell Compartment in Multiple Myeloma” PNAS USA (2007) 104:4048-4053.
Pietsch et al., “Medulloblastomas of the Desmoplastic Variant Carry Mutations of the Human Homologue ofDrosophilaPatched” Cancer Research (1997) 57:2085-2088.
Quirk et al.,“The Smoothened Gene and Hedgehog Signal Transduction inDrosophilaand Vertebrate Development” Cold Spring Harbor Symposium Quant. Biol. (1997) 62:217-226.
Rahman et al., “Alkaloids from Veratrum Album” Phytochemistry (1991) 1:368-370.
Rasmusson et al., “Azasteroids: Structure-Activity Relationships for Inhibition of 5-alpha-Reductase and of Androgen Receptor Binding” J. Med. Chem. (1986) 2298-2315.
Reifenberger et al., “Missense Mutations in SMOH in Sporadic Basal Cell Carcinomas of the Skin and Primitive Neuroectodermal Tumors of the Central Nervous System” Cancer Research (1998) 58:1798-1803.
Sheng et al., “Activation of the Hedgehog Pathway in Advanced Prostate Cancer” Molecular Cancer (2004) 3:29-42.
Shroff and Harper, “3-Aza-A-Homoandrostenes” J. Med. Chem. (1969) 190-191.
Sicklick et al., “Dysregulation of the Hedgehog Pathway in Human Hepatocarcinogenesis” Carcinogenesis (2006) 27:748-757.
Tas and Avci, “Rapid Clearance of Psoriatic Skin Lesions Induced by Topical Cyclopamine” Dermatology (2004) 209:126-131.
Thayer et al., “Hedgehog is an Early and Late Mediator of Pancreatic Cancer Tumorigenesis” Nature (2003) 425:851-856.
Van Der Horst et al., “Hedgehog Stimulates Only Osteoblastic Differentiation of Undifferentiated KS483 cells” Bone (2003) 33:899-910.
Watkins et al.,“Hedgehog Signaling Within Airway Epithelial Progenitors and In Small-Cell Lung Cancer” Nature (2003) 422:313-317.
Williams et al., “Identification of a Small Molecule Inhibitor of the Hedgehog Signaling Pathway: Effects on Basal Cell Carcinoma-Like Lesions” PNAS USA (2003) 100:4616-4621.
Xie et al., “Activating Smoothened Mutations in Sporadic Basal-Cell Carcinoma” Nature (1998) 391:90-92.
International Search Report for PCT/US05/30406, published as Wo/2006/026430, mailed on Apr. 4, 2006, 2 pages.
Supplementary Partial European Search Report for EP 05791140.6, mailed Nov. 26, 2007, 4 pages.
International Search Report and Written Opinion for PCT/US2008/056229, mailed Aug. 11, 2008, 11 pages.
Qualtrough et al., Int. J. Cancer (2004) 110(6):831-837.
Aboulkassim, Tahar O. et al., “Alteration of the PATCHED locus in Superficial Bladder Cancer”, Oncogene, vol. 22, (2003), pp. 2967-2971.
Bar, Elis E. et al., “Cyclopamine-Mediated Hedgehog Pathway Inhibition Depletes Stem-Like Cancer Cells in Gliobastoma”, Stem Cells, vol. 25, (2007), pp. 2524-2533.
B
Castro Alfredo C.
Grogan Michael J.
Lescarbeau Andre
Tremblay Martin
Aulakh Charanjit S
Fish & Richardson P.C.
Infinity Discovery, Inc.
LandOfFree
Cyclopamine lactam analogs and methods of use thereof does not yet have a rating. At this time, there are no reviews or comments for this patent.
If you have personal experience with Cyclopamine lactam analogs and methods of use thereof, we encourage you to share that experience with our LandOfFree.com community. Your opinion is very important and Cyclopamine lactam analogs and methods of use thereof will most certainly appreciate the feedback.
Profile ID: LFUS-PAI-O-2626122