Drug – bio-affecting and body treating compositions – Designated organic active ingredient containing – Having -c- – wherein x is chalcogen – bonded directly to...
Reexamination Certificate
2007-04-18
2008-08-05
Aulakh, Charanjit S (Department: 1625)
Drug, bio-affecting and body treating compositions
Designated organic active ingredient containing
Having -c-, wherein x is chalcogen, bonded directly to...
C546S115000, C546S015000, C514S278000
Reexamination Certificate
active
07407967
ABSTRACT:
The present invention provides compositions and methods for modulating smoothened-dependent pathway activation. The present invention provides analogs of cyclopamine that can be used to counteract the phenotypic effects of unwanted activation of a hedgehog pathway, such as resulting from hedgehog gain-of-function, Ptc loss-of-function or smoothened gain-of-function mutations. The compounds of the present invention are particularly useful in treating cancers.
REFERENCES:
patent: 6238876 (2001-05-01), Altaba
patent: 6291516 (2001-09-01), Dudek et al.
patent: 6432970 (2002-08-01), Beachy et al.
patent: 7230004 (2007-06-01), Adams et al.
patent: 2004/0072913 (2004-04-01), Tas et al.
patent: WO-95/18856 (1995-07-01), None
patent: WO-96/17924 (1996-06-01), None
patent: WO-00/41545 (2000-07-01), None
patent: WO-01/27135 (2001-04-01), None
patent: WO-01/49279 (2001-07-01), None
patent: WO-02/30462 (2002-04-01), None
patent: WO-2005/013800 (2005-02-01), None
patent: WO-2005/032343 (2005-04-01), None
patent: WO-2005/042700 (2005-05-01), None
Kitajima, J. et al.: Steroid alkaloids of fresh bulbs of Fritillaria Thunbergii MIQ. and of crude drug “BAI-NO” prepared therefrom. Heterocycles, vol. 15, pp. 791-796, 1981.
Alexandre et al., Genes Dev. (1996) 10:2003-2013.
Belloni et al., Nature Genetics (1996) 14:353-356.
Berman et al., Nature (2003) 425:846-851.
Chen et al., Genes and Development (2002) 16:2743-2748.
Cooper et al., Science (1998) 280:1603-1607.
Fan et al., Endocrinology (2004) 145:3961-3970.
Karhadkar et al., Nature (2004) 431:707-712.
Kubo et al., Cancer Research (2004) 64:6071-6074.
Lewis et al., Journal of Mammary Gland Biology and Neoplasia (2004) 2:165-181.
Quirk et al., Cold Spring Harbor Symp. Quant. Biol. (1997) 62:217-226.
Reifenberger et al., Cancer Res. (1998) 58:1798-1803.
Sheng et al., Molecular Cancer (2004) 3:29-42.
Tas et al., Dermatology (2004) 209:126-131.
Thayer et al., Nature (2003) 425:851-856.
Watkins et al., Nature (2003) 422:313-317.
Xie et al., Nature (1998) 391:90-92.
International Search Report for PCT/US05/30406, mailed on Apr. 4, 2006, 2 pages.
Lee et al., Journal of Agricultural and Food Chemistry (2003) 51(3):582-586.
Supplementary Partial European Search Report for EP 05791140.6, mailed Nov. 26, 2007, 7 pages.
Adams Julian
Castro Alfredo C.
Foley Michael A.
Janardanan Nair Somarajan Nair
Nevalainen Marta
Aulakh Charanjit S
Infinity Pharmaceuticals Inc.
Morrison & Foerster / LLP
LandOfFree
Cyclopamine analogues and methods of use thereof does not yet have a rating. At this time, there are no reviews or comments for this patent.
If you have personal experience with Cyclopamine analogues and methods of use thereof, we encourage you to share that experience with our LandOfFree.com community. Your opinion is very important and Cyclopamine analogues and methods of use thereof will most certainly appreciate the feedback.
Profile ID: LFUS-PAI-O-4014223